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Online Adaptive Radiotherapy Cervical Cancer With Reduced Margin for Cervical Cancer

Uterine Cervical Neoplasm Clinical Trial

Official title:
A Prospective Study to Evaluate Online Adaptive Radiotherapy in Cervical Cancer With Reduced Margin

Clinical Trial Summary

Online adaptive radiotherapy (oART) has demonstrated to be feasible to reduce planning target volume (PTV) margins for cervical cancer. To explore the value of reduced margins in oART for cervical cancer, we conducted a prospective clinical trial to determine the clinical efficacy and toxicity of reduced margins.

Clinical Trial Description

This is an investigator-initiated efficacious, single-center, open-label clinical trial study. This study hypothesizes that the use of reduced PTV margins in oART for cervical cancer could decrease toxicity and achieve more accurate dosimetric coverage. A dose of 50.4 Gy is delivered to clinical target volume (CTV) with reduced margin oART. Patients receive cisplatin based concurrent chemotherapy. The primary endpoint is acute toxicity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05880485
Study type Interventional
Source Peking Union Medical College Hospital
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date February 2, 2023
Completion date November 2025
View Details
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