Clinical Trials Logo
  1. Home
  2. Uterine Cervical Cancer
  3. NCT02095119

A Monoclonal Antibody, Nimotuzumab, as Treatment for Recurrent or Metastatic Cervical Cancer

Uterine Cervical Cancer Clinical Trial

Official title:
Phase I-II Study of Palliative Treatment With Nimotuzumab as a Second, Third Line or More of Treatment for Advanced or Metastatic Cervical Cancer

Clinical Trial Summary

The following is an open label, non comparative, pilot study of palliative treatment as a second, third line or more of treatment in patients with recurrent, persistent or Metastatic Cervical Cancer; it has a limited sample of 15 patients with the primary goal of evaluating the response (defined as: Complete, partial or stable disease) to treatment with a Monoclonal Antibody, Nimotuzumab, on a weekly basis + CDDP 50mg/m2/BSA as a single agent every 3 weeks for patients with good renal function (Creatinine clearance => 60) or Gemcitabine 800 mg/m2/BSA in patients with renal failure (Creatinine clearance <60).

Secondary objectives consist of evaluating disease-free survival, overall survival and assess patient tolerance to treatment with Nimotuzumab.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02095119
Study type Interventional
Source National Institute of Cancerología
Contact
Status Completed
Phase Phase 1/Phase 2
Start date July 2008
Completion date March 2014
View Details
See also
  Status Clinical Trial Phase
Terminated NCT01234480 - Intended Use Study of the BD SurePath Plus™ Pap
Completed NCT05022511 - Three Birds With One Stone N/A
Recruiting NCT04857528 - Detecting HPV DNA in Anal and Cervical Cancers
Completed NCT01755897 - A Multicenter, Prospective, Randomized Trial of Adjuvant Chemotherapy for Early-Stage Cervical Cancer Patients N/A
Recruiting NCT01667211 - Clinical Study of Albumin-bound Paclitaxel Plus Nedaplatin in Cervical Cancer Phase 2
Active, not recruiting NCT01226264 - Diffusion MRI; Predictive Value for Cervical Uterine Cancer Recurrence N/A
Recruiting NCT03961191 - DNA Methylation for Screening Uterine Cervical Lesions: A Case-control Study
Not yet recruiting NCT06254846 - Evaluation of First-void Urine as an Alternative to Cervical Sampling for Human Papillomavirus (HPV) Testing in Cervical Cancer Screening (Single-center Study). N/A
Enrolling by invitation NCT01393470 - Evaluation of Long-term HPV Vaccine Efficacy N/A
Terminated NCT00421096 - Radiochemotherapy Followed by Adjuvant Chemotherapy Based on Gemcitabine in Uterine Cervical Cancer Phase 2
Terminated NCT01284348 - To Determine Safe and Effective Dose of Sotatercept for the Treatment of Chemotherapy Induced Anemia in Participants With Advanced Non-small Cell Lung Cancer Phase 2
Recruiting NCT03961178 - A Cohort Study for the Following up of Conization
Terminated NCT02317302 - FDG Tumor Heterogeneity During Chemoradiation as a Predictor of Response in Patients With Cervical Cancer Phase 1
Not yet recruiting NCT05824494 - Cadonilimab Plus Nab -Paclitaxel for Patients With Recurrent, or Metastatic Cervical Cancer Resistant to Immune Checkpoint Inhibitors Phase 2
Completed NCT00184093 - Study of Gemcitabine and Concurrent Radiation Followed by Adjuvant Hysterectomy in Bulky Stage Ib and IIa Cervical Carcinoma Phase 1/Phase 2
Recruiting NCT03960879 - DNA Methylation for Screening Uterine Cervical Lesions
Recruiting NCT04886700 - Study of the SG001 Injection for Patients With Relapsed or Metastatic Uterine Cervical Cancer Phase 2
Enrolling by invitation NCT05231993 - Clinical Triage and Treatment of Atypical Glandular Cells (AGC) Detected in Screening N/A
Recruiting NCT02036164 - Adjuvant Chemotherapy for Locally Advanced Cervical Cancer Phase 3
Recruiting NCT04974424 - Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV