Endometrial Adenocarcinoma Clinical Trial
Official title:
A Phase 2 Study of Sunitinib Malate in Recurrent or Metastatic Endometrial Carcinoma
This phase II trial studies how well sunitinib malate works in treating patients with endometrial cancer that has come back after a period of improvement (recurrent) or has spread to other places in the body (metastatic). Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
PRIMARY OBJECTIVES:
I. To assess the objective response rate of recurrent or metastatic endometrial cancer to
sunitinib (sunitinib malate).
II. To assess the frequency of prolonged stable disease (as defined by percentage [%] of
patients alive and free from progressive disease at 6 months) in patients with recurrent or
metastatic endometrial cancer treated with sunitinib.
SECONDARY OBJECTIVES:
I. To assess time-to- progression, median overall survival, and rate of one-year survival in
patients with recurrent or metastatic endometrial cancer treated with sunitinib.
II. To assess the toxicity associated with sunitinib in patients with recurrent or metastatic
endometrial cancer.
OUTLINE:
Patients receive sunitinib malate orally (PO) once daily (QD) on days 1-28. Courses repeat
every 6 weeks in the absence of disease progression or unacceptable toxicity.
After the completion of study treatment, patients are followed up at 4 weeks and then every 3
months until relapse.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01935973 -
Trametinib With or Without GSK2141795 in Treating Patients With Recurrent or Persistent Endometrial Cancer
|
Phase 1 | |
| Active, not recruiting |
NCT03660826 -
Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone, and Olaparib Alone
|
Phase 2 | |
| Active, not recruiting |
NCT04106414 -
Study of BMS-986205 and Nivolumab in Endometrial Cancer or Endometrial Carcinosarcoma That Has Not Responded to Treatment
|
Phase 2 | |
| Completed |
NCT01642082 -
Dalantercept in Treating Patients With Recurrent or Persistent Endometrial Cancer
|
Phase 2 | |
| Completed |
NCT01208467 -
Prognostic Biomarkers in Patients With Endometrial Cancer
|
N/A | |
| Completed |
NCT01011933 -
Selumetinib in Treating Patients With Recurrent or Persistent Endometrial Cancer
|
Phase 2 | |
| Completed |
NCT00025467 -
Thalidomide in Treating Patients With Recurrent or Persistent Endometrial Cancer
|
Phase 2 | |
| Completed |
NCT01440998 -
Dasatinib, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer
|
Phase 1 | |
| Completed |
NCT00006089 -
Trastuzumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer
|
Phase 2 | |
| Active, not recruiting |
NCT00977574 -
Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer
|
Phase 2 | |
| Recruiting |
NCT05001282 -
A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRĪ±)
|
Phase 1/Phase 2 | |
| Completed |
NCT01968317 -
Megestrol Acetate Plus Metformin to Megestrol Acetate in Patients With Endometrial Atypical Hyperplasia or Early Stage Endometrial Adenocarcinoma
|
Phase 2 | |
| Completed |
NCT01225887 -
Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer
|
Phase 2 | |
| Completed |
NCT01005329 -
Intensity-Modulated Radiation Therapy, Cisplatin, and Bevacizumab Followed by Carboplatin and Paclitaxel in Treating Patients Who Have Undergone Surgery for Endometrial Cancer
|
Phase 2 | |
| Active, not recruiting |
NCT02208375 -
mTORC1/2 Inhibitor AZD2014 or the Oral AKT Inhibitor AZD5363 for Recurrent Endometrial and Ovarian
|
Phase 1/Phase 2 | |
| Completed |
NCT03716414 -
Evaluation of the Efficacy for Sentinel Lymph Node Policy in High-risk Endometrial Carcinoma
|
||
| Withdrawn |
NCT03836157 -
Mirvetuximab Soravtansine (IMGN853) and Bevacizumab in Patients With Endometrial Cancer
|
Phase 2 | |
| Completed |
NCT00095979 -
Ixabepilone in Treating Patients With Recurrent or Persistent Endometrial Cancer
|
Phase 2 | |
| Completed |
NCT00072176 -
Temsirolimus in Treating Patients With Metastatic or Locally Advanced Recurrent Endometrial Cancer
|
Phase 2 | |
| Active, not recruiting |
NCT03460483 -
Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care
|
N/A |