Uterine Atony Clinical Trial
Official title:
Up-down Determination of the ED90 of Oxytocin Infusions for the Prevention of Postpartum Uterine Atony in Parturients Undergoing Cesarean Delivery
This study is designed to determine the minimum effective dose (ED90) of infusions of
oxytocin for the prevention of uterine atony / postpartum hemorrhage and the need for
additional uterotonics, in low risk parturients presenting for an elective CD.
The primary outcome measure is the response of effective uterine contraction as either
satisfactory or unsatisfactory as determined by the obstetrician blinded to the oxytocin
infusion dose. Secondary outcomes will include need for additional uterotonics, calculated
intra-operative blood loss and presence of oxytocin related adverse effects.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
---|---|---|---|
Enrolling by invitation |
NCT02910115 -
Cooling the Uterus in C-section After Dysfunctional Labor
|
N/A | |
Withdrawn |
NCT02410655 -
An Evidence Based Protocol for Oxytocin Administration in Vaginal Delivery
|
Phase 4 | |
Completed |
NCT00790062 -
Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT
|
Phase 4 | |
Recruiting |
NCT01579201 -
ED90 Determination of Carbetocin for the Prevention of Uterine Atony in Women Undergoing an Elective Cesarean Delivery
|
Phase 4 | |
Completed |
NCT03867383 -
Calcium Chloride for Prevention of Uterine Atony During Cesarean
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT03584854 -
Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial
|
Phase 4 | |
Completed |
NCT02780245 -
Role of Tranexamic Acid Versus Uterine Cooling at Caesarean Section
|
Phase 4 | |
Withdrawn |
NCT03303235 -
Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections
|
Early Phase 1 | |
Completed |
NCT02229513 -
Uterine Cooling During Cesarean Delivery to Reduce Blood Loss and Incidence of Postpartum Hemorrhage
|
N/A | |
Not yet recruiting |
NCT06192836 -
Placental Removal Method And Uterine Massage On Preventing Postpartum Hemorrhage
|
||
Recruiting |
NCT03413917 -
Exploration and Determination of Genomic Markers Predictive of Uterine Atony
|
||
Withdrawn |
NCT01252342 -
Does Intramyometrial Oxytocin Improve Outcome in Elective Cesarean Delivery?
|
Phase 4 | |
Completed |
NCT04690153 -
Novel Approach of Hayman Uterine Compression Sutures for Management of Severe Atonic Postpartum Hemorrhage: Three Vertical Sutures
|
||
Completed |
NCT05027048 -
Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery
|
Phase 3 | |
Completed |
NCT01630187 -
Comparison of Two Doses of Carbetocin for Prevention of Uterine Atony, During Elective Cesarean Section
|
Phase 4 | |
Completed |
NCT01549223 -
Oxytocin And Uterotonic Agent Use For Cesarean Delivery
|
Phase 4 |