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Urolithiasis clinical trials

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NCT ID: NCT06438497 Recruiting - Urolithiasis Clinical Trials

The Effect of Different Body Positions and Channel Sheaths on RIRS

Start date: May 23, 2024
Phase: N/A
Study type: Interventional

Retrograde flexible ureteroscopy (RIRS) is currently the first-line treatment for renal stones < 2cm. Lower pole renal stones(LPS) are a difficult problem for urologists. The flexible negative pressure suction ureteral sheath(f-UAS) can facilitate RIRS to flush out the fragments and dust in time, and provide a clear vision and reduce the renal pelvis pressure(RPP) during operation.Standard lithotomy position is the most commonly used position for RIRS. Besides, T-tilt position is also available for RIRS in special cases. Investigators were inspired by this and proposed the lateral position, which is available in cases of LPS.In long-term practice, investigators have found that the change of position and the use of f-UAS can improve stone-free rate(SFR). Investigators aimed to conduct a prospective randomized controlled trial to compare the SFR of different positions and different ureteral sheaths.

NCT ID: NCT06384105 Recruiting - Urolithiasis Clinical Trials

Study of the Patient Radiation Dose During Five Endourological Procedures

PRDE
Start date: December 19, 2023
Phase: N/A
Study type: Interventional

In the medical world more and more procedures are performed with the use of ionizing radiation (x-ray), both diagnostic and therapeutic. The main and most known risk is the development of malignancies as a result of the use of ionizing radiation. Purpose of this study: To examine the patient radiation dose (PRD) if the frames per second (FPS) are set differently during the five most performed endourological procedures where fluoroscopy is used (insertion/replacement of ureteral stent, (mini-)percutaneous nephrolithotomy (PCNL/PNL), ureterorenoscopy (URS) and extracorporeal shock wave lithotripsy (ESWL/SWL)) and to propose an acceptable PRD for these procedures in a multicentric study.

NCT ID: NCT06373419 Recruiting - Clinical trials for Urolithiasis of Bladder

TFL vs MOSES Holmium Laser in the En-bloc Resection of Bladder Tumors

Start date: October 16, 2023
Phase: N/A
Study type: Interventional

The goal of this randomized clinical trial is to determine if there is difference in pathological and clinical outcomes between MOSES and TFL in the transurethral laser enucleation of bladder tumors. The main question it aims to answer is: Is there a difference in pathological and clinical outcomes between MOSES Holmium and Thulium Fiber Laser (TFL) in the transurethral laser enucleation of bladder tumors? Participants will randomized to either TFL of MOSES arm for their bladder resection procedure.

NCT ID: NCT06331546 Recruiting - Healthy Clinical Trials

Gut Oxalate Absorption in Calcium Oxalate Stone Disease

Start date: April 17, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will - ingest fixed diets containing low and moderately high amounts of oxalate for 5 days at a time - ingest a soluble form of oxalate and sugar preparations to test gut permeability - collect urine, blood, stool and breath sample during the fixed diets and the soluble oxalate test

NCT ID: NCT06330246 Recruiting - Urolithiasis Clinical Trials

O. Formigenes Colonization in Calcium Oxalate Kidney Stone Disease

Start date: April 17, 2024
Phase: N/A
Study type: Interventional

The goal of this trial is to test if colonization with the gut bacteria Oxalobacter formigenes leads to a reduction in urinary oxalate excretion in patients with calcium oxalate kidney stone disease. The study will recruit adult participants with a history of calcium oxalate kidney stones who are not colonized with Oxalobacter formigenes. Participants will - ingest fixed diets containing low and moderately high amounts of oxalate for 4 days at a time - collect urine, blood and stool samples during the fixed diets - ingest a preparation of live Oxalobacter formigenes to induce colonization with Oxalobacter formigenes

NCT ID: NCT06306222 Recruiting - Kidney Stone Clinical Trials

Thulium Fiber Laser vs. Holmium:YAG Laser for the Ureteroscopic Treatment of Patients With Urinary Stone Disease

Start date: November 23, 2023
Phase: N/A
Study type: Interventional

This is a randomized controlled trial which aims to compare the efficacy and safety of Thulium fiber laser (TFL) and holmium:yttrium-aluminum-garnet (Ho:YAG) laser ablation during the treatment of upper urinary tract stone disease with flexible ureteroscopy, demonstrating clinical superiority of TFL.

NCT ID: NCT06269783 Recruiting - Urolithiasis Clinical Trials

Dual-process Mechanisms of Action for sipIT Intervention Effects in Patients With Urolithiasis

Start date: January 10, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to clarify the fundamental processes underlying behavior change, maintenance, and adherence during and after a 3-month fluid intake intervention period.

NCT ID: NCT06176469 Recruiting - Urolithiasis Clinical Trials

Renal Colic and Urolithiasis in Poland

POLSTONE
Start date: December 1, 2023
Phase:
Study type: Observational

The aim of this study is to analyze the prevalence, effect on quality of life, and treatment-related behaviors for renal colic and urolithiasis in a population-representative sample of Poles. We will be using an Internet interview format for renal colic and urolithiasis evaluation. The study will include respondents representative for age and place of residence with adequate proportions of respondents from urban and rural areas.

NCT ID: NCT06152666 Recruiting - Bladder Cancer Clinical Trials

Day-case Endourology; Enablers, Barriers, Unexpected Outcomes

Start date: December 1, 2023
Phase:
Study type: Observational

A qualitative research study conducted in hospitals across England, in which staff members will be interviewed. We will interview staff who are directly or indirectly involved in delivering care for patients undergoing the operations of interest; namely bladder tumour resection, prostate resection or enucleation, and ureteroscopy for upper urinary tract stones. We hope to find out the reasons why some hospitals can perform day-case surgery with very high rates, and why others do not. We also hope to find out about any unexpected outcomes observed when performing day-case surgery for the operations of interest. Staff working in a range of different hospitals from across England with varying day-case rates will be interviewed. Hospitals in large city and more rural areas will be assessed. Interviews are anticipated to take place over a six month period. The study will end when "saturation" is achieved, whereby no new themes are identified through interviews. Saturation will be sought for each individual operation of interest.

NCT ID: NCT06092203 Recruiting - Pediatric ALL Clinical Trials

Quality of Life for Pediatric Urolithiasis

Elattar
Start date: February 1, 2023
Phase:
Study type: Observational [Patient Registry]

The aim of this study is to assess the quality of life (QoL) in pediatric patients with urinary stone disease.