Urinary Tract Infections Clinical Trial
Official title:
A Randomized, Controlled, Multicentre Trial of Collateral Damage on the Intestinal Microbiota Inferred by Temocillin Versus Cefotaxime in Patients Receiving Empirical Treatment for Febrile Urinary Tract Infections
This study will evaluate the ecological impact on the intestinal microbiota and compare the safety and efficacy of temocillin compared to cefotaxime, in empiric treatment of febrile UTI. Half of participants will receive temocillin and the other half will receive cefotaxime.
Temocillin is a narrow spectrum antibiotic with activity against gram negative bacteria
inclusive many ESBL producing bacteria. Temocillin is approved and marketed in a few European
countries since the 1980´s but not in Sweden.
The aim of the study is to find an ecological favorable alternative to cephalosporins in the
treatment of this common indication.
The hypothesis is that treatment with temocillin causes less disturbances on the intestinal
microbiota while at least comparable efficacy.
The study will be performed as an open prospective multicentre study with two parallel groups
comparing 2 g temocillin three times daily with 1-2 g cefotaxim three times daily for 7-10
days in male and female adult patients with febrile urinary tract infection.
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