Urinary Tract Infection Clinical Trial
Official title:
A Double-blind, Controlled, Parallel-group, Randomized, Multicenter Clinical Trial to Assess the Efficacy and Safety of a Herbal Drug Containing Centaury, Lovage Root and Rosemary Leaf (CLR) in Comparison to Fosfomycin Trometamol for the Treatment of Acute Lower Uncomplicated Urinary Tract Infections (uUTIs) in Women
To demonstrate non-inferiority of a non-antibiotic therapy with CLR versus an antibiotic treatment with fosfomycin trometamol in women suffering from acute lower uUTIs as measured by the proportion of patients who received an additional antibiotic treatment for acute lower uUTIs during the trial.
The trial is designed as a comparison of two different modes of action in order to look for
alternatives to antibiotic treatment of uncomplicated UTIs. Treatment with CLR is a
nonantibiotic therapy and is compared to an antibiotic treatment. Thus, the trial aim is to
reduce antibiotics use and moreover to reduce the pressure of developing bacterial resistance
against antibiotics due to widespread use, which is an additional advantage of the CLR
therapy.
The trial results are expected to demonstrate that antibiotic prescriptions in women for
treatment of lower uUTIs can be reduced by an alternative and safe non-antibiotic treatment.
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