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Corticosteroids for Children With Febrile Urinary Tract Infections — STARRS  

Urinary Tract Infection Clinical Trial

Official title:
Corticosteroids for Children With Febrile Urinary Tract Infections

Clinical Trial Summary

In this study the investigators will determine whether corticosteroids given at the time of urinary tract infection help prevent permanent damage to the kidneys.

Clinical Trial Description

Because host inflammatory response is the final and most important step in the formation of renal scars, the use of anti-inflammatory agents may be the best strategy to reduce renal scarring. In animal studies, the use of corticosteroids has been shown to be effective in preventing post-pyelonephritic scarring. We will conduct a randomized, double-blind, placebo-controlled trial to determine the efficacy of 3 days of daily adjuvant dexamethasone on the incidence of renal scarring 4 to 6 months after a first febrile urinary tract infection (UTI). We hypothesize that the proportion of children with UTI who develop renal scarring will be lower among children who are treated with both dexamethasone and antibiotics as compared with children treated with antibiotics alone. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01391793
Study type Interventional
Source University of Pittsburgh
Contact
Status Completed
Phase Phase 3
Start date September 2011
Completion date March 30, 2018
View Details
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