Clinical Trials Logo

Clinical Trial Summary

This study will test the hypothesis that constitutionally poorer Eustachian tube function predisposes to middle-ear pathology during a viral upper respiratory infection.


Clinical Trial Description

The most well supported immediate cause of Otitis media (OM) is a pre-existing or concurrent viral upper respiratory tract infection (vURI). However, not all vURI episodes cause OM and a variety of predisposing factors has been suggested to explain this selectivity. Based on our preliminary work using a model of experimental viral infections in adults, we hypothesize that the constitutional efficiency of the Eustachian tube (ET) to supply the middle ear (ME) with gas and thereby stabilize ME pressure at near ambient is a primary risk factor for OM during vURI. Here, we test the hypothesis that constitutionally poorer ET function (F) predisposes to ME pathology during a vURI. Specifically, we will use ETF testing protocols relevant to the pressure-chamber to evaluate constitutional ETF in ≈ 160 susceptible, adult volunteers who will be exposed to rhinovirus as part of our funded study entitled "Social and Psychological Risks for Infectious Disease" (PI: S. Cohen, PI: CHP subcontract: WJ Doyle) and document the ETF and ME responses to infection over a 5-day post-exposure, cloister period.

Also, using protocols relevant to the pressure-chamber, we will evaluate constitutional ETF in 80 children who will be enrolled into our funded study entitled "Role of Virus and Genetic Susceptibility in Otitis Media" (PI: CM Alper) and followed for vURI and OM from October through April. From both data sets, we will extract measures of ETF efficiency and determine using logistic regression with appropriate control variables (e.g. demographic data etc) if a single or combination of ETF variables predicts an abnormal ME response in rhinovirus infected adults or OM during a rhinovirus cold in children. ;


Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional


Related Conditions & MeSH terms


NCT number NCT00694421
Study type Observational
Source University of Pittsburgh
Contact
Status Completed
Phase N/A
Start date January 2008
Completion date May 2012

See also
  Status Clinical Trial Phase
Completed NCT03711292 - Using Behavioral Science to Reduce Inappropriate Antibiotic Use in Acute Care Settings N/A
Completed NCT01168778 - Improving Communication During Pediatric Visits for Acute Respiratory Illness N/A
Terminated NCT00187785 - Doctor-Patient Communication in Spanish N/A
Completed NCT00405509 - The Natural History of Viral Upper Respiratory Infections in Children Aged 6 to Less Than 14 Years N/A
Completed NCT00189475 - Evaluate the Potential of Montelukast to Prevent Nasal Symptomatology During Colds Phase 4
Completed NCT04468204 - Use of Novel Sinusonic Device for Prevention of Community Acquired Upper Respiratory Infection (URI) N/A
Active, not recruiting NCT05666752 - Effect of Intake of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement N/A
Completed NCT00255307 - Pilot Evaluation of CVT-E002 in Pediatric Upper Respiratory Tract Infection. Phase 2
Suspended NCT05035420 - A Noninvasive Multimodal Biosensing Device for Screening and Monitoring Response to Treatment of Infectious Respiratory Diseases N/A
Recruiting NCT06244615 - Clinical Trial of a Mouth and Throat Rinse for the Treatment of Acute Sore Throat N/A
Completed NCT02694679 - Randomized Controlled Trial of Social Network Targeting in Honduras N/A
Completed NCT05352581 - BD Veritor™ At-Home and BD Veritor™ Professional
Active, not recruiting NCT02943551 - Dialogue Around Respiratory Illness Treatment N/A
Completed NCT01657643 - Effect of Probiotics on Health-related Quality of Life in College Students With Upper Respiratory Infections N/A
Completed NCT02110732 - Lactobacillus Rhamnosus GG in the Middle Ear and Adenoid Tonsil N/A
Completed NCT03884777 - Incidence and Risk of Influenza in Myasthenic Patients
Completed NCT00796315 - Study Evaluating the Pharmacokinetics of Doxylamine Succinate in Children Phase 1
Completed NCT00642681 - Effects of URI on Diabetic Subjects Utilizing Technosphere Insulin After a Meal Challenge Phase 2
Completed NCT00259831 - Efficacy of Cold-FX (CVT-E002) in the Prevention of Upper Respiratory Tract Infections in Healthy Adults Phase 3
Completed NCT04588376 - Improving Antibiotic Prescribing for Pediatric Respiratory Infections by Family Physicians With Peer Comparison N/A