Difference in Central Fatigue During Two Ultra-endurance Practices: Running vs. Cycling

Ultra-marathon Runners Clinical Trial

— FAT-CENTR  

Official title:

Difference in Central Fatigue During Two Ultra-endurance Practices: Running vs. Cycling

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04511858
• Other study ID #: 19CH217
• Secondary ID: 2020-A01714-35
• Status: Completed
• Phase: N/A
• Start date: March 5, 2021
• Est. completion date: July 15, 2021

Study information

• Verified date: November 2021
• Source: Centre Hospitalier Universitaire de Saint Etienne
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The mechanisms contributing to muscle fatigue in extreme long-duration exercise bouts are poorly understood. Ultra-endurance exercise is an excellent model for the study of adaptive responses to extreme loads and stress and it is an especially useful model for documenting the origins of central fatigue. This protocol will compare fatigue during and after ultra-endurance exercise bouts that result in moderate lower-limb tissue damage (i.e. cycling) or significant damage (i.e. running). The results of this protocol will allow us to further understanding of the reasons for major central fatigue, i.e. within the central nervous system, in ultra-endurance.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: July 15, 2021
• Est. primary completion date: May 28, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Specialist in endurance and ultra-endurance. in the 2 disciplines: running and cycling (triathletes, duathletes or trailers achieving at least 30% of their training volume in cycling), and having at least finished one long distance event in the last 2 years,
• Affiliated or beneficiary of a social security scheme.
• Signature of the consent form

Exclusion Criteria:

• Any subject who has been injured in the 3 months prior to the protocol
• Anyone with chronic joint pathologies (e.g.: repetitive sprains, patellar or ligament problems).
• Any subject with chronic or central neurological pathologies
• Any subject with a contraindication to magnetic stimulation
• Use of neuro-active substances likely to alter cortico-spinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) on the study.
• Contraindication to the application of a magnetic field:
• Heart or respiratory insufficiency.
• Subject with a cardiac pace maker.
• Cardiac valve wear and serious cardiovascular diseases.
• Presence of prosthetic material or ferromagnetic foreign bodies in the head.
• Presence of cochlear implants or ocular prosthetic material.
• History of neurosurgical interventions.
• Neurological diseases that may affect brain structures and cognitive abilities (e.g., intracranial tumour, multiple sclerosis, history of stroke or traumatic brain injury).
• History of comitiality, contralateral knee disease or musculoskeletal disease.
• Any subject participating at the same time in another interventional experiment requiring physical exercise.
• Any subject who has taken corticosteroids within 3 months (inhalation, infiltration or history of prolonged corticosteroid therapy).
• Any subject under guardianship or curatorship

Related Conditions & MeSH terms

• Fatigue
• Ultra-marathon Runners

Intervention

Other:
• maximum effort test on a cycloergometer
5 h test on cycloergometer
• maximum effort test on a treadmill
5 h test on treadmill

Locations

Country	Name	City	State
France	CHU Saint-Etienne	Saint-Étienne

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Saint Etienne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximum level of voluntary activation of relative central fatigue	measured in isometric mode of the knee extensors, between the value before and immediately after a 5-hour cycling or running event at the same relative intensity	Before and immediately after 5h exercise
Secondary	Maximum level of voluntary activation of fatigue centrale absolute	measured in isometric mode of the knee extensors, between the value before the 5h cycling or running and the value after absolute exhaustion	Before and immediately after 5h exercise
Secondary	Maximum level of voluntary activation with electrical evoked activation	tests with measurement of the maximum voluntary with evoked electrical between the value before and immediately after a 5-hour cycling or running event at the same relative intensity	Before and immediately after 5h exercise
Secondary	Spinal excitability	thoracic spine stimulation for the recording of thoracic motor evoked potentials	Before and immediately after 5h exercise
Secondary	Corticospinal excitability	stimulation of the motor cortex for recording motor evoked potentials	Before and immediately after 5h exercise
Secondary	Cortical excitability	ratio between stimulation of the motor cortex and thoracic spine stimulation	Before and immediately after 5h exercise
Secondary	Measurement of isometric force values	subjects sitting on a Cybex type seat, with the knee and hip angle set at 90°. The foot will be attached to a strain-gauge sensor using a velcro strap attached to the ankle above the medial malleolus.	Before and immediately after 5h exercise
Secondary	Measurement of speed, force and power values	assessment of fatigue in dynamic mode (calculation of the force/speed profile)	Before and immediately after 5h exercise
Secondary	Red blood cells	blood sample	Before and immediately after 5h exercise
Secondary	Platelets	blood sample	Before and immediately after 5h exercise
Secondary	White blood cells	blood sample	Before and immediately after 5h exercise
Secondary	Hemoglobin	blood sample	Before and immediately after 5h exercise
Secondary	Mean corpuscular hemoglobin concentration	blood sample	Before and immediately after 5h exercise
Secondary	C-reactive protein	blood sample	Before and immediately after 5h exercise
Secondary	Creatine PhosphoKinase	blood sample	Before and immediately after 5h exercise
Secondary	Interleukines	blood sample	Before and immediately after 5h exercise
Secondary	Lactate	blood sample	Before and immediately after 5h exercise
Secondary	Measurement of the time maintained at the speed corresponding to the 2nd ventilatory threshold	On treadmill	Before and immediately after 5h exercise
Secondary	measurement of the time maintained at the power corresponding to the 2nd ventilatory threshold	On Cycloergometer	Before and immediately after 5h exercise