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Surgical and Oncological Outcomes in Patients With Ulcerative Colitis-associated Rectal Cancer — UC-RectalK  

Ulcerative Colitis Clinical Trial

Official title:
Surgical and Oncological Outcomes in Patients With Ulcerative Colitis Associated Rectal Cancer: a Retrospective Study

Clinical Trial Summary

This is a retrospective observational study to investigate the short-term surgical outcomes, and long-term oncological outcomes of patients diagnosed with Ulcerative colitis and rectal cancer.

Clinical Trial Description

Inflammatory Bowel Disease (IBD) is a risk factor for the development of colorectal cancer (CRC). Despite improved targeted screening and timely prophylactic resection, up to 15% of all IBD-related mortality can be attributed to CRC. Previous reports suggest that IBD patients present with CRC at an earlier age and with more advanced disease than those with sporadic CRC. The literature is limited, however, with respect to colitis-associated rectal cancer (CARC), which has unique considerations such as surgical approach and the use of neoadjuvant therapy. Although total proctocolectomy is generally the procedure of choice for those with CARC, recent reports reported acceptable oncological outcomes after ileal pouch-anal anastomosis (IPAA) and ileorectal anastomosis (IRA). The impact of the type of surgical procedure on the oncologic outcome in patients with CARC is not well defined. The aim of this study is to investigate short-term surgical outcomes (postoperative complications at 30 days after surgery) and long-term oncological outcomes (disease-free survival) of CARC patients undergoing different surgical approaches. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04659148
Study type Observational
Source Istituto Clinico Humanitas
Contact Annalisa Maroli
Phone +390282247776
Email annalisa.maroli@humanitas.it
Status Recruiting
Phase
Start date October 1, 2020
Completion date April 1, 2021
View Details
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