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TUDCA as a Therapy for Ulcerative Colitis (UC) — TUDCA  

Ulcerative Colitis Clinical Trial

Official title:
A Phase I Open Label Study of the Efficacy and Safety of Tudca in Ulcerative Colitis

Clinical Trial Summary

This is a Phase I open label study examining the efficacy and safety of TUDCA (tauroursodeoxycholic acid) in ulcerative colitis treatment.

Clinical Trial Description

TUDCA (tauroursodeoxycholic acid) is a dietary supplement that has shown to reduce cellular stress related to inflammation. In this Phase I study, patients with active ulcerative colitis will be receive TUDCA for six weeks. Safety and tolerability will be assessed. Efficacy will be assessed using ulcerative colitis disease activity measurements as well as markers of intestinal inflammation before and after treatment. The overall goal of this project is to determine TUDCA can provide a new therapeutic option with a desirable safety profile for patients with ulcerative colitis focused on the inflamed intestinal epithelium. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04114292
Study type Interventional
Source Washington University School of Medicine
Contact Matthew A Ciorba, MD
Phone 3142730301
Email mciorba@wustl.edu
Status Recruiting
Phase Phase 1
Start date January 17, 2019
Completion date July 31, 2022
View Details
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