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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT00292175
Other study ID # 06/NBI2/10
Secondary ID
Status Recruiting
Phase N/A
First received February 14, 2006
Last updated September 21, 2007
Start date February 2006

Study information

Verified date September 2007
Source London North West Healthcare NHS Trust
Contact Brian Saunders, MD, FRCP
Phone 0044208235
Email b.saunders@imperial.ac.uk
Is FDA regulated No
Health authority United Kingdom: National Health Service
Study type Interventional

Clinical Trial Summary

The purpose of the study is to determine whether a new colonoscopic viewing technique called narrow band imaging (NBI) helps doctors detect more patients with at leat one pre-cancerous area (dysplasia associated lession or mass, MALMs) than conventional colonoscopy using white light alone.


Description:

Colorectal cancer is the second commonest cause of cancer death. Patients with colitis have a substantially increased risk of death from colorectal cancer which increases with lenght of time the patient has had colitis. This can be as high as a 30% chance of colorectal cancer after 30 years of colitis. Colonoscopic surveillance of colitis patients has been shown to reduce the risk of colorectal cancer and allow detection at an earlier stage, but even with meticulous examination, some precancerous lesions or cancers are missed.

Precancerous lesions in colitis are difficult to see and endoscopist have used spraying dye on the lining of the bowel (chromoendoscopy) successfully to improve detection of abnormal areas: however this is time consuming and requires extra time and equipment and despite the benefits seen in multiple studies is not widely used in routine clinical practice in the UK.

Narrow band imaging (NBI) is a technique that relies on light filters to improve contrast for the smallest blood vessels in the bowel lining which shows up precancerous areas as they have a richer vascular network. It is sometimes described as "digital chromoendoscopy" as the images produced are similar to chromoendoscopy, but it is much simpler and quicker to use. With magnification it allows assessment of the fine mucosal surface pattern (pit pattern) of lesion which allows and assessment of their likelihood of being precancerous. Autofluorescence endoscopy uses short wavelength light and light filters to produce a false colour image of the bowel lining where polyps stand out. These techniques have been used with some success in the oesophagus and stomach but little work is available for the colon.

We aim to see if NBI with magnification is better that standard colonoscopy for detecting precancerous areas. This is likely as it produces images similar to chromoendoscopy which is already shown to help. If a potentially precancerous area is found we will use other types of endoscopy, particularly NBI autofluorescence to see if these techniques are helpful for discriminating between pre-cancerous and non pre-cancerous areas


Recruitment information / eligibility

Status Recruiting
Enrollment 110
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- petients with colitis who meet surveillance criteria

- patients over 18 years of age

Exclusion Criteria:

- pregnant patients

- unable or unwilling to give informed consent

- patients with severe active colitis who would be unsafe to endoscope

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic


Related Conditions & MeSH terms


Intervention

Procedure:
Narrow Band Imaging

colonoscopy


Locations

Country Name City State
United Kingdom North West London Hospitals NHS Trust - St Mark's London Middlesex
United Kingdom Nottingham Univesrity Hospitals NHS Trust, Queen's Medical Centre Nottingham

Sponsors (2)

Lead Sponsor Collaborator
London North West Healthcare NHS Trust Nottingham University Hospitals NHS Trust

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Effectiveness of NBI versus Light endoscopy
Secondary Are more precancerous lessions found in total with NBI?
Secondary Are more advanced precancerous lesions found with NBI?
Secondary Are more patients found with more that one precancerous lesion with NBI?
Secondary How Many lessions are successfully completely removed via the endoscope?
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