Ulcerative Colitis in Remission Clinical Trial
Official title:
What is the Level of Serum Leucine-rich α 2-glycoprotein (LRG) Which Predicts Endoscopic Remission in Patients With Ulcerative Colitis?
We attempt to clarify the serum leucine-rich α 2-glycoprotein (LRG) level which predicts endoscopic remission in ulcerative colitis patients in this study. Colonoscopy with histology is performed when endoscopic remission will be predicted based on serum LRG values, irrespective of symptoms. Serum LRG levels were analyzed by an enzyme-linked immunosorbent assay.
Aim: Serum leucine-rich α 2-glycoprotein (LRG) may be a noninvasive biomarker for monitoring disease activity in patients with ulcerative colitis (UC). We attempted to clarify the LRG level which predicts endoscopic remission in UC patients in this study. Methods: Patients with UC were consecutively enrolled with the measurement of serum LRG. Colonoscopy with histology were performed when endoscopic remission was predicted based on serum LRG values, irrespective of symptoms. Serum LRG levels were analyzed by an enzyme-linked immunosorbent assay. For the evaluation of UC activity, clinical remission was defined as score 1 or 0 using the partial Mayo score and endoscopic remission was defined as score 0 using the Mayo endoscopic subscore. And Geboes score was used for histopathological findings. We analyzed the area under receiver operating characteristic (ROC) curves to evaluate the diagnostic ability of LRG for predicting endoscopic remission of UC. In addition, the clinical features of UC patients with endoscopic remission were examined. ;
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