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Ulcerative Colitis Acute clinical trials

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NCT ID: NCT05998213 Recruiting - Ulcerative Colitis Clinical Trials

Transfer of Feces in Ulcerative Colitis 2

TURN2
Start date: December 5, 2018
Phase: Phase 2
Study type: Interventional

The goal of this placebo-controlled randomised multicenter trial is to evaluate the efficacy and safety of anaerobic prepared donor fecal microbiota transplantation (FMT) compared to autologous FMT in patient with ulcerative colitis. Participants will receive 4 treatments with frozen FMT via both upper and lower gastro-intestinal route (infusion via duodenal tube and enemas). Donors are selected based on microbiota profile.

NCT ID: NCT05867329 Recruiting - Clinical trials for Ulcerative Colitis Acute

A Trial for Acute Severe Ulcerative Colitis

Start date: September 30, 2023
Phase: Phase 4
Study type: Interventional

The goal of this trial is to create personalized treatments for each patient admitted to the hospital with acute severe ulcerative colitis (ASUC). The study will test the feasibility and acceptability of these treatment strategies among patients and physicians so that the study team can later do a larger trial to test whether the medication treatment pathways help patients avoid colectomy while ensuring patient's are safe.

NCT ID: NCT05466890 Recruiting - Ulcerative Colitis Clinical Trials

Phase 2a To Evaluate PL-8177 in Subjects With Active Ulcerative Colitis (UC)

PL8177-205
Start date: September 15, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare PL8177 (a melanocortin receptor agonist) to placebo (in a 3:1 ratio-meaning that for every 3 people that get the active drug, one will receive placebo). The study treatment will be for 8 weeks. The study will measure safety and the body's ability to handle PL8177 and look at the improvement and healing of the intestine after 8 weeks of treatment. The study will include adult males and nonpregnant, nonlactating females with acute Ulcerative Colitis (UC).