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Ulcer clinical trials

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NCT ID: NCT02772406 Recruiting - Ulcerative Colitis Clinical Trials

Linked Color Imaging vs. White Light for Colorectal Dysplasia in Ulcerative Colitis

Start date: April 2016
Phase: N/A
Study type: Interventional

The purpose of the study is to determine whether a new colonoscopic viewing technique called Linked color imaging(LCI) helps endoscopists detect more dysplasia lesions in ulcerative colitis patients than conventional colonoscopy using white light alone.

NCT ID: NCT02770040 Completed - Ulcerative Colitis Clinical Trials

Optimising Infliximab Induction Therapy for Acute Severe Ulcerative Colitis

PREDICT UC
Start date: July 18, 2016
Phase: Phase 4
Study type: Interventional

The purpose of this study is to identify whether an Accelerated or Intensified Infliximab induction regimen is superior to Standard induction in Acute Severe Ulcerative Colitis in an open label multi-centre randomised controlled trial.

NCT ID: NCT02769494 Withdrawn - Crohn's Disease Clinical Trials

The Efficacy of Topical Mesalazine Sustained-Release Tablets in Crohn's Disease Patients With Oral Ulcer

Start date: March 2016
Phase: Phase 3
Study type: Interventional

This study aims at evaluating efficacy and safety of topical using Mesalazine Sustained-Release Tablets in in the treatment of oral ulcers in patients with Crohn's disease.

NCT ID: NCT02768974 Recruiting - Ulcerative Colitis Clinical Trials

Open Label Study to Assess Safety, PK and Explore Efficacy of OPRX-106 in Patients With Active Mild to Moderate Ulcerative Colitis

Start date: September 2016
Phase: Phase 2
Study type: Interventional

This is a proof of concept, randomized, open label, 2-arm study of OPRX-106 in subjects with active mild to moderate ulcerative colitis. Eligible subjects will be enrolled and randomized to receive 2 mg or 8 mg of OPRX-106 administered orally, once daily for 8 weeks.

NCT ID: NCT02764229 Terminated - Colitis, Ulcerative Clinical Trials

Open-label Extension Study to Assess Safety and Tolerability of LYC-30937-EC in Subjects With Active Ulcerative Colitis

Start date: November 1, 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to allow subjects completing study LYC-30937-2001 the opportunity to receive LYC-30937-EC 25 mg.

NCT ID: NCT02762500 Completed - Colitis, Ulcerative Clinical Trials

An Efficacy and Safety Study of LYC-30937-EC in Subjects With Active Ulcerative Colitis

Start date: July 2016
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the efficacy and safety of LYC-30937-EC given orally once daily in subjects with active ulcerative colitis (UC) defined as a total Mayo score (TMS) of 4-11 inclusive, with an endoscopic score of ≥ 2 and a rectal bleeding score of ≥ 1 at screening.

NCT ID: NCT02761512 Completed - Gastric Ulcer Clinical Trials

Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Gastric Ulcer

Start date: May 2016
Phase: Phase 3
Study type: Interventional

To demonstrate non-inferiority of CJ-12420 to lansoprazole 30 mg capsule in terms of therapeutic efficacy, and to confirm safety of CJ-12420, after once daily oral administration of CJ-12420 50 mg, 100 mg or Lansoprazole 30 mg capsule in gastric ulcer patients.

NCT ID: NCT02760615 Withdrawn - Crohn Disease Clinical Trials

Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study

Start date: November 1, 2016
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate in a step-wise approach the disease drug-drug interaction (DDI) potential for vedolizumab to indirectly affect the exposure of cytochrome P-450 (CYP) substrate drugs by modulating pro-inflammatory cytokines in participants with ulcerative colitis (UC) or Crohn's disease (CD) who are treated with vedolizumab.

NCT ID: NCT02750280 Completed - Clinical trials for Neuropathic Diabetic Foot Ulcer

A Longitudinal Study to Evaluate an Extracellular Matrix (MatriStem®) for the Treatment of Diabetic Foot Ulcers

M-S-DFU-RCT
Start date: June 2015
Phase: N/A
Study type: Interventional

This ia a prospective controlled longitudinal study to evaluate the effects of MatriStem® plus standard local wound care versus standard local wound care alone in the treatment of diabetic foot ulcers (DFUs), as assessed by incidence of complete wound healing by 16 weeks and ulcer recurrence with a 2 year follow-up.

NCT ID: NCT02749630 Completed - Ulcerative Colitis Clinical Trials

A Safety Study of Intravenously Administered UTTR1147A in Healthy Volunteers (HVs), Participants With Ulcerative Colitis (UC), and Participants With Crohn's Disease (CD)

Start date: April 11, 2016
Phase: Phase 1
Study type: Interventional

This is a randomized, observer-blinded, placebo-controlled study to evaluate safety, tolerability, immunogenicity, and pharmacokinetics of repeat dosing of intravenous (IV) UTTR1147A. The study will consist of a repeat dose escalation in HVs, in participants with UC, and in participants with CD across multiple sites.