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Ulcer clinical trials

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NCT ID: NCT06328010 Enrolling by invitation - Burns Clinical Trials

An Observational Clinical Registry to Collect Safety and Efficacy Data on Wound Care in Medical Centers

SIDDX
Start date: April 1, 2024
Phase:
Study type: Observational [Patient Registry]

Collect data on various wound treatments and their related wound healing process, in real life settings. Analyze the safety and efficacy of wound treatments, including: advanced biological/synthetic grafts and standard of wound care treatments.

NCT ID: NCT05888259 Enrolling by invitation - Diabetic Foot Ulcer Clinical Trials

Plantar Pressure Distribution in Diabetic Foot Ulcer

PPDDFU
Start date: September 17, 2021
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to find out the changes in peak pressure and pressure-time integral after twelve weeks from the initial utility of foot insoles and eight weeks later as a follow-up in diabetic foot ulcers. Participants will be randomly assigned to foot insole, medication, and wound care (study group) or medication and wound care (control group).

NCT ID: NCT05804890 Enrolling by invitation - Diabetic Foot Ulcer Clinical Trials

Comparing Activated Carbon Cloth Dressing and Silver-Based Dressing in a Diabetic Foot Ulcer Population

ZORFLEX
Start date: August 1, 2022
Phase:
Study type: Observational

One of the common complications of diabetes mellitus (DM) is Diabetic Foot Ulcer (DFU), which can subsequently lead to infections, gangrene, amputation or even death, if necessary care is not taken to curb with the condition. Despite the rapid advancements in the medical industry, diabetic foot ulcer (DFU) is considered as a major factor of morbidity and a leading cause of hospitalizations among diabetic patients. The risk of ulcer progression that may ultimately lead to amputation is elevated upon the development of DFU. It is estimated that DFU contributes approximately 50-70% of all lower limb amputations. In addition to rendering emotional and physical distress, DFU is also responsible for causing productivity and financial losses that lower the quality of life. The economic burden of the patients is further aggravated by the medical expenditure involved in the healing of DFU and/or lower extremity amputation. This study focuses on usage of a modern primary wound dressing in managing diabetic foot ulcer. The primary dressing used in this study is an activated carbon cloth dressing, which is applied directly to the wound bed and the "holes" in the net give access to the activated carbon which is made up of millions of micropores and within the walls of these micro pores, there is presence of electrostatic forces known as Van der Waals forces, which helps to trap and kill microorganisms such as MRSA and Pseudomonas aeruginosa. In addition, the dressings can regulate matrix metalloproteinases (MMPs) which are responsible for prolonged inflammation in chronic wounds like diabetic foot ulcers, and able to promote fibroblast migration and accelerate granulation tissue growth via its conductivity.

NCT ID: NCT05203471 Enrolling by invitation - Diabetic Foot Clinical Trials

Crossing the Divide: Piloting Integrated Care to Reduce Amputations Among Rural Patients With Diabetic Foot Ulcers

Start date: February 16, 2023
Phase: N/A
Study type: Interventional

This project directly addresses the escalating national rate of major (above-ankle) amputations due to diabetic foot ulcers; it focuses on rural patients, who face 37% higher odds of major amputation compared to their urban counterparts. The project pilots the first integrated care model adapted to rural settings, an approach that has reduced major amputations in urban settings by approximately 40%. Pilot data will be used to improve recruitment and retention strategies and provide preliminary evidence of efficacy needed to conduct a robust, statewide efficacy trial.

NCT ID: NCT03935386 Enrolling by invitation - Clinical trials for Chronic Venous Hypertension With Ulcer

Standard Compression Therapy With/Without Application of Skin Allograft (Theraskin) for Venous Leg Ulcer Treatment

Start date: November 2015
Phase: N/A
Study type: Interventional

This study will compare the efficacy of using standard compression therapy for treatment of chronic venous leg ulcers vs. the standard compression therapy with the additional use of the application of a human allograft (Theraskin)

NCT ID: NCT02813187 Enrolling by invitation - Venous Stasis Ulcer Clinical Trials

Venous Leg Ulcer and Lymphedema Registry

VLULR
Start date: May 2016
Phase:
Study type: Observational [Patient Registry]

This is an observational, longitudinal real world registry of venous leg ulcers created from electronic health record data obtained in the course of clinical care. Data from certified electronic health records transmit data as part of the requirement to share data with a specialty registry under Objective 10 of Meaningful Use of an EHR.

NCT ID: NCT02619734 Enrolling by invitation - Sickle Cell Disease Clinical Trials

Autologous Bone Marrow Stem Cells for Chronic Leg Ulcer Treatment in Sickle Cell Disease

Start date: August 2006
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of autologous bone marrow stem cell implantation for the treatment of leg ulcer in adult patients with sickle cell disease.

NCT ID: NCT02565264 Enrolling by invitation - Ulcer Clinical Trials

Effect of Plasma Derived Exosomes on Cutaneous Wound Healing

Start date: September 2015
Phase: Early Phase 1
Study type: Interventional

This study is an open prospective clinical trial. The objective is to evaluate the effect of autologous exosomes rich plasma on cutaneous wound healing. The participants are patients with intractable cutaneous ulcers (e.g. rheumatic disease, peripheral arterial disease, chronic venous insufficiency, decubitus or burns). The participants will be treated autologous exosomes rich plasma every day for 28 days. The cutaneous wound healing will be evaluated by the length, width and depth of the wound.

NCT ID: NCT02402374 Enrolling by invitation - Clinical trials for Diabetic Foot Ulcers

Evaluate the Safety and Efficacy of RegenKit Autologous PRP Gel for the Treatment of Diabetic Foot Ulcer

Start date: April 12, 2018
Phase: N/A
Study type: Interventional

Autologous platelet-rich plasma (PRP) gel was reported to have very good outcomes in the treatment of foot ulcers in pilot studies and retrospective uncontrolled trials. Therefore, a larger randomized, placebo-controlled clinical trial will be useful to determine whether platelet-rich plasma is safe and effective for the treatment of diabetic foot ulcers (DFU).

NCT ID: NCT02375802 Enrolling by invitation - Pressure Ulcer Clinical Trials

Adipose-Derived Stromal Cells (ASC's) for Pressure Ulcers

Start date: July 2015
Phase: Phase 1
Study type: Interventional

This pilot study of 12 patients will test the safety and efficacy of applying autologous, adipose-derived stromal cells (ASCs), uncultured, on a Stage III or IV pressure ulcer or diabetic foot ulcers. Patients will undergo a minimal risk liposuction procedure to withdraw 50-100 cc of adipose tissue. The tissue would be processed to extract the stromal layer of cells that contain stem cells. The ASCs would be injected into a fibrin sealant to be applied to the wound. Patients would be followed for 6 weeks to assess wound healing and tolerance of the treatment.