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NCT04907838 Clinical Trial

Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes

Type2 Diabetes Clinical Trial

Official title:
Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT04907838
Other study ID # s-20180040
Secondary ID
Status Active, not recruiting
Phase N/A
First received
Last updated
Start date May 1, 2018
Est. completion date July 30, 2021

Study information
Verified date May 2021
Source University of Southern Denmark
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study evaluates the role of endothelin in insulin stimulated vasodilation and glucose uptake. The subjects will complete an hyperinsulinemic euglycemic clamp with and without blockade of the endothelin receptors.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 22
Est. completion date July 30, 2021
Est. primary completion date July 30, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 40 Years to 65 Years
Eligibility Inclusion Criteria: - Type 2 diabetes OR healthy control (no type 2 diabetes) - BMI<32 Exclusion Criteria: - heart disease - pregnancy or birth within 3 month - smoking - Kidney disease - beta-blockers - insulin treatment (for type 2 diabetics)

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Insulin clamp
Continous infusion insulin + glucose
• BQ123
Continuous infusion of Insulin + glucose + BQ123
• BQ123 + BQ788
Continous infusion of insulin + glucose + BQ123 + BQ788

Locations
Country Name City State
Denmark Cardiovascular and Renal Research Odense

Sponsors (2)
Lead Sponsor Collaborator
University of Southern Denmark The University of Texas at Arlington

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary Glucose infusion rate Glucose infusion rate required to maintain euglycemia during insulin clamp with and without endothelin blockade 3.5 hours
Primary Leg blood flow Effect of endothelin receptor blockade on leg blood flow (ultrasound Doppler) during insulin clamp with and without endothelin blockade 3.5 hours
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