Effects of Exercise on sRAGE Levels and Cardiometabolic Risk Factors

Type 2 Diabetes Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01542775
• Other study ID #: Exer(sRAGE)
• Status: Completed
• Phase: N/A
• First received: February 20, 2012
• Last updated: March 1, 2012
• Start date: January 2010

Study information

• Verified date: February 2012
• Source: Korea University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine the effects of exercise on diverse cardiometabolic risk factors and indicators of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. primary completion date: December 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• type 2 diabetes

• stable body weight

• sedentary lifestyle

Exclusion Criteria:

• smoked cigarettes

• cardiovascular disease

• chronic kidney

• chronic liver disease

• pregnant or breastfeeding

• any other major illness

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Type 2 Diabetes

Intervention

Behavioral:
• Aerobic Exercise Group
12 weeks Aerobic exercise
• Control Group
maintaining usual activities

Locations

Country	Name	City	State
Korea, Republic of	Eulji University School of Medicine	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Korea University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change from baseline in soluble receptor for advanced glycation endproducts (sRAGE) after 12 weeks of aerobic exercise		12 weeks	No
Secondary	anthropometric parameters	body weight, waist circumference, body fat percentage, visceral fat area	12 weeks	No
Secondary	biochemical parameters	HbA1c, apolipoprotein B, free fatty acid	12 weeks	No
Secondary	energy expenditure	activity energy expenditure, total energy expenditure	12 weeks	No