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Perioperative Adverse Cardiovascular Event in Type-2 Diabetic Patients — DMPACE  

Type 2 Diabetes Clinical Trial

Official title:
Association of Changes in NPY, CGRP, SP and TRPV1 With Perioperative Adverse Cardiovascular Event in Type-2 Diabetic Patients

Clinical Trial Summary

The study was designed to investigate the correlation between perioperative adverse cardiovascular events and the degeneration of sensory nerves in patient diagnosed with type 2 diabetes mellitus, undergoing elective non-cardiac surgery.

Clinical Trial Description

The study was designed to investigate the correlation between perioperative adverse cardiovascular events and the degeneration of sensory nerves in patient diagnosed with type 2 diabetes mellitus, undergoing elective non-cardiac surgery. Diabetes mellitus and peripheral sensory nerve degeneration will be diagnosed via clinical evaluation. Serum levels of constituent neuropeptides, including neuropeptide Y (NPY), calcitonin and substance P (SP) and calcitonin gene related peptide (CGRP), and transient receptor potential vanilloid 1 (TRPV1), a molecular nociceptor in peripheral sensory nerves will be quantitatively evaluated. The clinical and the biochemical consequence will be compared between the cohorts of diabetic and non-diabetic patients. The differences and the correlations will be analyzed. The results of the study may reveal whether or not the perioperative adverse cardiovascular events in diabetic patients are correlated with degeneration of peripheral sensory nerves and the alterations in the neuropeptides and TRPV1 are potentially applicable for evaluation of the risk of cardiovascular events in perioperative period in diabetic patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04579406
Study type Observational
Source Second Hospital of Shanxi Medical University
Contact Zheng Guo, M.B., Ph.D.
Phone +863513365790
Email guozheng713@yahoo.com
Status Recruiting
Phase
Start date October 15, 2020
Completion date June 30, 2023
View Details
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