Type 1 Diabetes Clinical Trial
— GlycogenOfficial title:
Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla
Verified date | December 2019 |
Source | University of Minnesota |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain glucose metabolism in humans. We will measure brain glycogen turnover and content in normal controls and subjects with diabetes under conditions of modest hyper-and hypoglycemia.
Status | Completed |
Enrollment | 10 |
Est. completion date | December 2017 |
Est. primary completion date | December 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Age 18-65 - Healthy control - Must be able to provide informed consent - Type 1 diabetes with hypoglycemia unawareness with hemoglobin A1c < 7.5% - Poorly controlled diabetics with hemoglobin A1c > 7.5% - Subjects with hypoglycemia unawareness must report an inability to recognize at least some blood glucose values <58 mg/dL during the 3 months prior to the study. Exclusion Criteria: - Over 300 pounds - Claustrophobic - History of ischemic heart disease, arrhythmia, of seizure disorder - Pregnant - On medications known to alter blood flow or carbohydrate metabolism - Have internally located pieces of metal |
Country | Name | City | State |
---|---|---|---|
United States | University of Minnesota | Minneapolis | Minnesota |
Lead Sponsor | Collaborator |
---|---|
University of Minnesota |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Brain Glycogen Turnover Rate | 1 month |
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