Effect of Coenzyme Q10 on Diabetic Children

Status Not yet recruiting

Clinical Trial Summary

Determine the effect of Coenzyme Q10 on random blood sugar and glycosylated haemoglobin

Clinical Trial Description

Type 1 diabetes mellitus is an autoimmune disease that leads to destruction of insulin producing pancreatic Beta cells. Individuals with type 1 diabetes requires life long insulin replacement with multiple daily insulin injection. daily,insulin pump therapy or the use of an automated insulin delivery system. without insulin ,diabetic ketoacidosis develops and is life threatening. In addition to insulin Therapy ,glucose monitoring with a continuous glucose monitor and a blood glucose monitor if continuous glucose monitor is unavailable is recommended . Coenzyme Q10 supplementation has beneficial effects on glycemic control especially in diabetes , and 100-200 mg per day of Co Q10 could achieve the greatest benefit which could provide a basis for the dietary guidelines of Co Q10 in patients with glycemic disorders . Co Q10 with a known antiinflammatory and antioxidant has beneficial effects on endothelial function and therefore minimize the microvascular and macrovascular complication in patients with type 1 diabetes mellitus. Administration of Co Q10 for 3 months in type 1 diabetes mellitus in pediatric patients was will tolerated but had no favorable effect on endothelial dysfunction or metabolic parameters . Co Q10 in addition to improving the metabolic hyperglycemia , it improve Hb A1c and the lipid profile. patients with type 1 diabetes , especially poorly controlled had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10 which may be an indicator of increased oxidative stress ,so Co Q10 has an antioxidant effects. Researches on this topic are limited on pediatrics and investigators search for it and will see the result.(clinical trial) Co Q10 is present in the forms of soft gel capsules ,oral spray , hard gel capsules and tablets . Co Q10 approved from age of 2 years old to 18 years old . ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06361680
Study type	Interventional
Source	Assiut University
Contact	Faisal Alkhateeb Ahmad Abdullah, Professor
Phone	01003858676
Email	faisalalkhateeb@aun.edu.eg
Status	Not yet recruiting
Phase	Early Phase 1
Start date	October 30, 2024
Completion date	November 30, 2025

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.