Type 1 Diabetes Mellitus Clinical Trial
Official title:
Effect of Metformin as add-on Therapy on Glycemic Control and Other Diabetes‑Related Outcomes in Type 1 Diabetic Patients:a Open-label,Self-control Study
Aim Evidence of a possible connection between gut microbiota and several physiological processes linked to type 1 diabetes is increasing. However, the effect of multistrain probiotics in people with type 1 diabetes remains unclear. This study investigated the effect of metformin as add-on therapy on glycemic control and other diabetes-related outcomes in people with type 1 diabetes.
Design An open-label, add-on, self-control clinical trial. Setting Diabetes clinic of a
teaching hospital in Shenzhen China Participants A total of 20 participants with type 1
diabetes, aged 18-60 years, will be recruited and treated with metformin as add-on therapy
with insulin for 12 weeks.
Outcomes Primary outcomes were glycemic control related parameters, and secondary outcomes
were anthropomorphic variables, lipid profile, blood pressure and high-sensitivity C-reactive
protein. The gut microbiota profile will be analyzed before and after intervention .
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