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Type 1 Diabetes Prediction and Prevention (DIPP) Study — DIPP  

Type 1 Diabetes Mellitus Clinical Trial

Official title:
Type 1 Diabetes Prediction and Prevention (DIPP) Study

Clinical Trial Summary

The Type 1 Diabetes Prediction and Prevention (DIPP) Study in Finland is a population-based long-term clinical follow-up study established since 1994 in three university hospitals in Finland to understand the pathogenesis of type 1 diabetes (T1D), predict the disease, and find preventive treatment.

Clinical Trial Description

Briefly, cord blood samples are collected and HLA-DR-DQ genotypes are determined from newborn babies. Families with a newborn baby carrying a DR-DQ genotype associated with increased risk for T1D are invited to participate in regular follow-up at the age of 3, 6, 9, 12, 18 and 24 months, and thereafter once a year until the age of 15 years or until T1D is diagnosed. Clinical details including maternal diet during pregnancy and lactation and child's diet starting from the age of 3 months are recorded, blood samples are collected, and serum autoantibodies associated with development of T1D are measured. Children who develop beta-cell specific autoimmunity are followed more intensively with measurements of glucose metabolism parameters such as glycated haemoglobin A1c (HbA1c), oral glucose tolerance tests (OGTT) and intravenous glucose tolerance tests (IVGTT). In the DIPP Study more than 1000 children have developed multiple islet autoantibodies and more than 450 of these have progressed to clinical T1D. It has been estimated that 5% of children in the follow-up will develop T1D and 60% of future T1D cases will be reached by the current screening and follow-up strategy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03269084
Study type Observational
Source University of Oulu
Contact Riitta Veijola, MD PhD
Phone +358407422328
Email riitta.veijola@oulu.fi
Status Recruiting
Phase
Start date November 7, 1994
Completion date December 31, 2024
View Details
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