Type 1 Diabetes Mellitus Clinical Trial
Official title:
Tissue-Specific Metabolic Reprogramming in Diabetic Complications. Glycemic Clamp Studies to Determine the Real Time Synthesis Rates of Glucose Derived Metabolites in Individuals With Type 1 Diabetes and Healthy Controls.
We will perform blood sugar studies to assess changes in metabolic (biochemical processes that occur within us) profiles associated with high blood sugar and diabetes.
Objective: To assess steady state and dynamic metabolite changes in subjects with type 1
diabetes with and without microvascular complications and to understand intrinsic differences
from non-diabetics in metabolite levels and flux.
The hypothesis is that diabetic complications arise from tissue-specific metabolic
reprogramming resulting in alterations in fuel utilization which lead to dysfunction of the
tissue. To test this hypothesis, we will use sensitive and specific mass spectrometer based
metabolomic analysis to measure steady state metabolite levels in plasma and urine from
controls subjects and subjects with T1DM, without and with diabetic complications during
euglycemic and hyperglycemic clamp studies.
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