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Efficacy of N-acetylcysteine to Prevent Anti-tuberculosis Drug-induced Liver Injury: A Randomized Controlled Trial

Tuberculosis Clinical Trial

Official title:
Efficacy of N-acetylcysteine to Prevent Anti-tuberculosis Drug-induced Liver Injury: A Randomized Controlled Trial

Clinical Trial Summary

To determine the efficacy of NAC to prevent clinically significant anti-TB drugs induced liver injury (AT-DILI).

Clinical Trial Description

Tuberculosis is one of the most important infectious diseases and treatment related hepatitis from anti-TB drug was observed for 5-28%. Slow acetylator status in the N-acetyltransferase 2 (NAT2) genotype is a significant risk factor of anti-tuberculosis drug-induced liver injury (AT-DILI). We assessed the effect of N-acetylcysteine to prevent hepatitis from anti-TB drug in Thai population. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05738681
Study type Interventional
Source Mahidol University
Contact Kittichai Samaithongcharoen, MD
Phone 0991494469
Email pao_kitichai@hotmail.com
Status Recruiting
Phase Phase 2/Phase 3
Start date September 9, 2022
Completion date May 31, 2023
View Details
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