Multiplex PCR -Microarray-based Assay in the Detection of Mycobacterium

Status Completed

Clinical Trial Summary

The study will use the VereMTB tool for rapid diagnosis of TB or non-tuberculous mycobacterium (NTM) pulmonary infections in hospitalised patients, with positive results in acid-fast bacilli smears, which are emerging in many regions of the world.

Clinical Trial Description

Delay in diagnosis and treatment of tuberculosis was common in hospitalised patients all around the world, and was associated with poorer outcomes, including respiratory failure and mortality. Rapid and accurate tools for diagnosis of TB is of great importance in initial treatment and for better treatment outcomes. Other than TB, non-tuberculous mycobacterium (NTM) pulmonary infections are emerging in many regions of the world. These bacterium are more common to be found in respiratory specimens than MTB. With similar clinical presentation of NTM pulmonary infections and pulmonary TB, misdiagnosis of NTM pulmonary infections to pulmonary TB would lead to unnecessary intake of anti-TB medications and delay of the initiation of corresponding treatment. This test aims to detect MTB as well differentiate the NTM species involved in pulmonary infections simultaneously using VereMTB. ;

Study Design

Related Conditions & MeSH terms

Mycobacterium Infections
Non-Tuberculous Mycobacterial Pneumonia
Tuberculosis

Clinical Trial Details

NCT number	NCT03794284
Study type	Observational
Source	Chinese University of Hong Kong
Contact
Status	Completed
Phase
Start date	February 28, 2019
Completion date	July 31, 2022

View Details

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