Tuberculosis Clinical Trial
Official title:
A Phase II Open Label Trial to Investigate the Effect of Schistosoma Mansoni (Sm) Infection on the Immunogenicity of a Candidate TB Vaccine, MVA85A, in BCG-vaccinated African Adolescents
Mycobacterium tuberculosis (M. tb) is a pathogen with worldwide distribution which infects
humans causing tuberculosis (TB), a transmissible disease resulting in very high mortality
and morbidity; development of an effective vaccine is a global health priority.
Over a billion people worldwide are infected with one or more helminths. Helminths are
parasitic worms, of which Schistosoma mansoni is one species. There is some evidence that
helminth infection may affect a person's response to a vaccine. In this trial the
investigators hope to investigate whether Schistosoma mansoni infection affects adolescents'
responses to a candidate TB vaccine called MVA85A, as adolescents are a crucial target group
for an effective TB vaccine.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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