Tuberculosis, Pulmonary Clinical Trial
Official title:
Cost-effectiveness of Two Forms of Delivery of Directly Observed Treatment in a Demonstration Area of the DOTS Strategy in Colombia
- Tuberculosis ( TB ) remains a major global public health problems and actions to ensure
the diagnosis and complete treatment of all cases is the priority for the control of
this disease. Despite the availability of effective anti-tuberculosis medications,
there are still high levels of nonadherence to treatment. The nonadherence increases
the morbidity and mortality of patients, decreases the cure rate, increases the
community transmission and the increase of chronically ill patients enables the
emergence of multi - drug resistant and increases treatment costs.
- Despite the knowledge about different forms of cost-effective delivery of DOT (directly
observed treatment), recognition of the need to establish the DOT strategy related to
the context from local studies, in Colombia and in Cali we hadn't had made studies
similar than this one that establish the cost and results of the current DOT delivery
strategy and to identify other ways to improve adherence and cure rate for the TB
patients at reasonable cost for both: health services and families
- Therefore, this research aims to compare the cost -effectiveness of current DOT
delivery method with an alternative extra- institutional delivery of anti -TB treatment
in urban areas of Cali. A cost-effectiveness study was conducted from the institutional
and familiar perspective with prospective information collection.
We compared two strategies for anti- TB treatment delivery: one institutional in which
patients went to health institutions to receive treatment and other extra- institutional in
which the medication was delivered in the place of choice for treating patients.
Measuring the effectiveness ( compliance and cure ) was made from a controlled clinical
trial , randomized , partially blinded . The measurement of family and institutional costs ,
direct and indirect , will be based on the activities.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Health Services Research
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