Triple Negative Breast Cancer Clinical Trial
Official title:
Routine MRI Screening Versus Symptom-directed Surveillance for Brain Metastases Among Patients With Triple Negative and HER2+ Metastatic Breast Cancer (MBC): A Single-centre Randomized Pilot Study
In this study, 50 women with either HER2+ or triple negative metastatic breast cancer but no
known brain metastases will be recruited at the Sunnybrook Odette Cancer Centre. They will be
randomized to undergo either routine MRI screening of their brain every 4 months for 1 year
or standard-of-care (MRI only if symptoms of brain metastases develop). Patients will
complete questionnaires about quality of life and cancer-related anxiety throughout the
study. To determine why some cancers spread to the brain and others do not, blood samples
will be collected to analyze the genetic makeup of patients' breast cancers. Finally, a novel
MRI imaging technique that detects abnormal metabolism in the brain will be used to help
detect brain metastases even earlier than the standard MRI.
If results are promising, we will conduct a large multi-centre randomized trial to determine
whether screening for brain metastases can help them live longer with improved quality of
life.
Please see trial details below. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
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Phase 2 | |
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Phase 1/Phase 2 | |
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||
| Completed |
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|
Phase 3 | |
| Recruiting |
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|
Phase 2 | |
| Terminated |
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Phase 2 | |
| Recruiting |
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Phase 2 | |
| Withdrawn |
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|
||
| Withdrawn |
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Phase 2 | |
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Phase 2 | |
| Terminated |
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Phase 1/Phase 2 | |
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||
| Completed |
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Phase 1 | |
| Recruiting |
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Early Phase 1 | |
| Active, not recruiting |
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|
Phase 1/Phase 2 |