Clinical Trials Logo
  1. Home
  2. Tricuspid Valve Disease
  3. NCT03546231

Characteristics and Prognosis of Moderate or Severe Tricuspid Regurgitation — EPIT  

Tricuspid Valve Disease Clinical Trial

Official title:
Clinical and Echocardiographic Characteristics and Prognosis of trIcuspid regurgiTation (EPIT): Prospective and Retrospective Follow-up of a Cohort of Patients With Moderate or Severe Tricuspid Regurgitation

Clinical Trial Summary

The tricuspid valve : its evaluation is relatively difficult in echocardiography and the management of tricuspid valve diseases remains poorly codified.

Clinical Trial Description

The tricuspid valve is often called the "forgotten valve" because its evaluation is relatively difficult in echocardiography and the management of tricuspid valve diseases remains poorly codified. In developed countries, TR is mainly functional, related to a remodeling of the right cavities in response to an increase in the load conditions. This remodeling induces a dilation of the tricuspid ring and / or a "tenting" of the tricuspid leaflets. Once TR is present, a vicious circle settles because TR increases right ventricle dilation. Transthoracic echocardiography is the key examination allowing noninvasive, quantification and assessment of hemodynamic repercussions of TR. TR remains asymptomatic for a long time, often diagnosed with a significant delay at the stage of advanced right heart failure. At this stage, the surgical risk is important, at least more important than for left heart valve diseases and it is therefore essential to define the right time for proposing valvular surgery to patients. Indeed, TR is an independent factor of mortality and only surgical treatment improves the prognosis. Current guidelines remain vague given the low number of prognostic studies and of their contradictory results often influenced by the significant comorbidities of patients, the presence of pulmonary hypertension or left heart valve disease. Only a minority of patients (<1%) is referred to surgery because operative mortality is often judged unacceptable in elderly patients or in cases of advanced right ventricular dysfunction. The constitution of a prospective and retrospective cohort will improve the state of knowledge on etiologies, natural history, prognosis and management of patients with moderate or severe TR. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03546231
Study type Observational
Source Centre Hospitalier Universitaire, Amiens
Contact Christophe TRIBOUILLOY, Pr
Phone 03 22 45 58 85
Email Tribouilloy.Christophe@chu-amiens.fr
Status Recruiting
Phase
Start date March 2, 2018
Completion date July 2025
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06001489 - The Effects of 360-degree Virtual Reality on Pre-procedural Anxiety in Patients Awaiting Elective Cardiac Surgery Involving a Sternotomy N/A
Active, not recruiting NCT04950192 - Philips Intracardiac Echocardiography (ICE) Clinical Registry
Terminated NCT04665583 - Prehab Prior to Undergoing Tricuspid Intervention
Recruiting NCT05797519 - Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation N/A
Not yet recruiting NCT06137807 - TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV) N/A
Recruiting NCT04231461 - Quality of Life After Cardiac Surgery
Completed NCT03239262 - Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation N/A
Not yet recruiting NCT06235385 - European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study
Recruiting NCT03859102 - Enhanced Recovery After Cardiac Surgery N/A
Recruiting NCT04097145 - Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial N/A
Recruiting NCT05742906 - CorMatrix Cor TRICUSPID ECM Valve Replacement - Pivotal Study N/A
Recruiting NCT05961150 - PROMISE: Percutaneous peRipheral cannulatiOn for Minimally-InvaSive Heart Valve surgEry
Recruiting NCT02397668 - CorMatrix Cor TRICUSPID ECM Valve Replacement Study N/A
Recruiting NCT04482062 - TRISCEND II Pivotal Trial N/A
Active, not recruiting NCT05064514 - Investigation of a Transcatheter Tricuspid Valved Stent Graft in Patients With Carcinoid Heart Disease N/A
Recruiting NCT05913908 - EFS of the DUO System for Tricuspid Regurgitation (TANDEM II) N/A
Recruiting NCT05848284 - Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( VISTA-US) N/A