The Trans-cutaneous Effects on Physiological Tremor Entertainment During tACS

Tremor, Limb Clinical Trial

Official title: The Trans-cutaneous Effects on Physiological Tremor Entertainment During tACS

Status Completed

Clinical Trial Summary

Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method that works by passing alternating electric current between electrodes where at least one of them is attached to the head. This has been shown to have effects on the motor system, cognition and behavior. The exact mechanism by which tACS causes such effects is not fully understood. Some studies suggests a contribution from the stimulated peripheral nerves present in the scalp rather than direct brain effects. To test this hypothesis two arms will be done. First, 12 subjects (arm 1) will be stimulated using focused 4x1 montage with gel-filled cup-electrodes over the motor cortex and the effects will be compared between anesthetized and non-anesthetized scalp. The effects of anesthetizing the scalp will be tested on three different stimulation amplitudes off (0 mA), low (0.5 mA) and high (2.5 mA). Then, 10 subjects (arm 2) will be stimulated over the contralateral arm to exclude any direct brain stimulation effects and to test if peripheral nerve stimulation can entrain the tremor. Three outcome measurements will be measured during the experiments which are: tremor entrainment, sensation intensity and sensation threshold.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Essential Tremor
• Tremor
• Tremor, Limb

• NCT number: NCT04065022
• Study type: Interventional
• Source: KU Leuven
• Status: Completed
• Phase: N/A
• Start date: June 20, 2017
• Completion date: January 16, 2018