Trauma Clinical Trial
Official title:
At What Point is Blood Transfusion Futile in Trauma?: A Retrospective Study of Ultra Massive Transfusion Protocol in Adult Trauma Patients Undergoing Surgery Within 24 Hours and Effects on Mortality and Clinical Outcomes
Verified date | March 2024 |
Source | University of Southern California |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to determine the effects of ultraMTP (>/=30 units pRBC within 24 hours) in trauma patients on mortality and secondary outcomes. The aim is to determine if there is a set number of pRBC units transfused in adult trauma patients undergoing surgery within 24 hours, after which mortality is inevitable and further transfusions are futile.
Status | Completed |
Enrollment | 3000 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - >/= 18 years old - trauma patient - undergoing surgery within first 24 hours of admission - received blood products within 24 hours of admission Exclusion Criteria: - <18-years-old - no surgery within the first 24 hours - did not receive blood products within the first 24 hours |
Country | Name | City | State |
---|---|---|---|
United States | Keck School of Medicine of the University of Southern California | Los Angeles | California |
Lead Sponsor | Collaborator |
---|---|
University of Southern California | Medical College of Wisconsin, Tulane University School of Medicine, University of Arkansas, University of California, Davis, University of California, Irvine, University of Chicago, University of Miami, University of Texas |
United States,
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* Note: There are 22 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 24-hour mortality | 24-hour mortality (yes/no) | 24 hours | |
Secondary | ICU length of stay | ICU length of stay (days) | through study completion, an average of 1 year | |
Secondary | hospital length of stay | hospital length of stay (days) | through study completion, an average of 1 year | |
Secondary | mechanical ventilator days | mechanical ventilator days | through study completion, an average of 1 year | |
Secondary | complications | complications (yes/no) | through study completion, an average of 1 year | |
Secondary | Multiple organ system failure | Multiple organ system failure (yes/no) | through study completion, an average of 1 year | |
Secondary | In-hospital mortality | In-hospital mortality (yes/no) | through study completion, an average of 1 year | |
Secondary | 30-day mortality | 30-day mortality (yes/no) | 30 days | |
Secondary | discharge disposition | discharge disposition | through study completion, an average of 1 year |
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