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PREVENTion of Clot in Orthopaedic Trauma — PREVENT CLOT  

Trauma Clinical Trial

Official title:
PREVENTion of Clot in Orthopaedic Trauma (PREVENT CLOT): A Randomized Pragmatic Trial Comparing the Complications and Safety of Blood Clot Prevention Medicines Used in Orthopaedic Trauma Patients

Clinical Trial Summary

The purpose of this study is to compare aspirin versus low-molecular weight heparin (LMWH) (Enoxaparin) as a thromboprophylaxis in patients who sustain a fracture.

Clinical Trial Description

Patients who sustain orthopaedic trauma are at an increased risk of venous thromboembolism (VTE), including fatal pulmonary embolism (PE). Current guidelines recommend low-molecular-weight heparin (LMWH) for VTE prophylaxis in orthopaedic trauma patients. However, emerging literature in total joint arthroplasty patients suggests the potential clinical benefits of VTE prophylaxis with aspirin. This trial aims to determine if aspirin is non-inferior to LMWH for thromboprophylaxis in fracture patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02984384
Study type Interventional
Source Major Extremity Trauma Research Consortium
Contact
Status Completed
Phase Phase 3
Start date April 24, 2017
Completion date February 18, 2022
View Details
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