Transposition of Great Vessels Clinical Trial
Official title:
Influence of Physical Training on Cardiopulmonary Exercise Capacity and Right Ventricular Function in Patients With D-TGA and Atrial Switch Operation.
In transposition patients after atrial switch operation, the morphological right ventricle serves as the systemic ventricle. These patients often develop signs of heart failure. It is not known, whether physical training can safely be recommended in these patients- like heart failure guidelines recommend training in patients with normal anatomy. Furthermore it is not known, whether these TGA-patients benefit from training with respect to cardiopulmonary exercise capacity.
This is a randomized, controlled, prospective trial on the safety of physical training in
TGA patients after atrial switch operation.
In transposition patients after atrial switch operation, the morphological right ventricle
serves as the systemic ventricle. These patients often develop signs of heart failure. It is
not known, whether physical training can safely be recommended in these patients- like heart
failure guidelines recommend training in patients with normal anatomy. Furthermore it is not
known, whether these TGA-patients benefit from training with respect to cardiopulmonary
exercise capacity.
Primary endpoints are Systemic Ventricle Ejection Fraction and Volumes, Exercise Capacity.
Secondary endpoints are Echo Diastolic Function, as well as laboratory markers of heart
failure.
;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Diagnostic
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