Clinical Trials Logo
  1. Home
  2. Transgenderism
  3. NCT04971447
  4. Details
NCT04971447 Clinical Trial

Extracellular Vesicles and Endothelial Function in Transgender Subjects

Transgenderism Clinical Trial

— Evinge  

Official title:
Effects of Plasma Extracellular Vesicles on Endothelial Function in Transgender Subjects

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT04971447
Other study ID # 21.03.30.69624
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date August 2022
Est. completion date January 2024

Study information
Verified date July 2021
Source Central Hospital, Nancy, France
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Cardiovascular diseases are the leading cause of mortality. In women, the prevalence of cardiovascular diseases is lower and the presentation of coronary events often atypical. The lack of evidence is related in part to the methodology of studies not considering sex as an essential biological variable. Hormonal treatment is prescribed in transgender subjects to promote the development of sexual characteristics of the desired sex. Early cardiovascular effects of hormonal treatment have been reported in transgender men, while long-term mortality is higher in transgender women. The aim of this project is to study the effects of gender affirming hormonal treatment on arterial stiffness in young transgender subjects followed at the University Hospital of Nancy.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 136
Est. completion date January 2024
Est. primary completion date September 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 49 Years
Eligibility Inclusion Criteria: - Trasgender subject demanding gender affirming hormonal therapy Exclusion Criteria: - Previous hormonal therapy - Pregnancy - Chronic disease - Cancer - Obesity - Drug abuse - Alcohol - Tabac

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• gender affirming hormonal treatment in transgender men
testosterone enanthate
• gender affirming hormonal treatment in transgender women
GnRH agonists + estrogen

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Central Hospital, Nancy, France

Outcome
Type Measure Description Time frame Safety issue
Primary pulse wave velocity measurement of arterial stiffness 24 months
See also
  Status Clinical Trial Phase
Recruiting NCT06093724 - Prospective Imaging Assessment of Perineo-pelvic Static's Evolution After Sexual Reassignment Surgery in MtF Transgender Patient, by Peno-scrotal Inversion Vaginoplasty Technique (TRANSPELV) N/A
Recruiting NCT04977765 - Cardiometabolic Health in Transgender Males
Recruiting NCT06074796 - The Determinants of Fertility Preservation in TRANSgender Patients.
Completed NCT04454970 - Safe Access for Bladder Entry in Transgender Men Following Penile Reconstruction N/A
Completed NCT04708600 - Effectiveness of Speech Therapy in Trans Women. N/A
Terminated NCT04551144 - Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors
Completed NCT04545450 - Effects of Testosterone Plus Dutasteride or Placebo on Muscle Strength, Body Composition and Metabolism in Transmen Phase 3
Recruiting NCT05663892 - Drug-Drug Interaction Study in Trans Women Living With HIV Phase 4
Completed NCT05666102 - Transgender Men's Perspectives on HIV Risk and HIV Prevention Interventions N/A
Recruiting NCT04838249 - Effects of Cross-sex Hormone Therapy on Eating Behavior, Metabolism, Energy Balance and Cardiovascular System
Not yet recruiting NCT06434805 - An Education Initiative to Reduce Stigma Towards Sex Workers and Sexual Minorities Among Nursing Students N/A
Recruiting NCT05883553 - Epithesis Versus Prosthesis in Post-phalloplasty Transgender Patients. N/A
Not yet recruiting NCT04154358 - Implementing HPV DNA Self-Collection to Increase Rates of Cervical Cancer Screening in Transgender Men N/A
Recruiting NCT04254354 - Transgender Men, Non-binary Persons and Testosterone Treatment BODY IDENTITY CLINIC
Completed NCT04969003 - Reducing Transphobia Among Adolescents Through a Brief Video Intervention N/A
Completed NCT06149065 - Factors Associated With the Acne Severity Among Transmen Population: a Cross-sectional Study
Terminated NCT04275310 - Microeconomic Intervention to Reduce HIV Transmission in Economically Disadvantaged Transgender Women N/A
Not yet recruiting NCT05415930 - Evaluation of an Adaptative, Multidisciplinary, Reach-out Program, Facilitating Pre Exposition HIV Prophylaxis (PrEP) Prescription and Retention in Care, in a Group of Trans Womens (TW) at High Risk of HIV Infection.
Completed NCT04515654 - Supporting Trans Identities and Occupational Justice Through Narrative Informed Theatre: Supporting Trans Identities and Occupational Justice Through Narrative Informed Theatre N/A
Recruiting NCT05761678 - Quality of Life of Transgender People - Implementation and Monitoring of an Online Cohort (e-QoL-Trans)