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Ventilator-associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation — VATICAN  

Tracheobronchitis Clinical Trial

Official title:
Multicenter Randomized Clinical Trial of Antimicrobial Treatment in Ventilator-associated Tracheobronchitis

Clinical Trial Summary

The Ventilator Associated tracheobronchitis Initiative to Conduct Antibiotic evaluation (VATICAN) trial is a national, multicenter, non-inferiority trial in ICU patients comparing antibiotic treatment for 7 days versus clinical observation without antibiotic treatment for patients with ventilator-associated tracheobronchitis.

Clinical Trial Description

There is no consensus on the need for antibiotic treatment for ventilator-associated tracheobronchitis (VAT). There's a lack of high-quality clinical data on this subject, and although some observational studies recommend antibiotic treatment for VAT, some guidelines do not. The VATICAN is a prospective, randomized, single-blinded (analysis), non-inferiority trial evaluating antibiotic treatment for patients with ventilator-associated tracheobronchitis. Patients with clinically diagnosed tracheobronchitis will be randomized to receive antibiotics for 7 days versus clinical observation without antibiotic treatment for VAT. The primary hypothesis is that clinical observation without antibiotic treatment is noninferior to 7-day antibiotic course. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05266066
Study type Interventional
Source Hospital Sirio-Libanes
Contact Bruno M Tomazini, MD
Phone 5511982839173
Email bruno.mtomazini@hsl.org.br
Status Recruiting
Phase N/A
Start date July 11, 2022
Completion date December 1, 2026
View Details
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