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Apatinib for Advanced Sarcoma: Results From Multiple Institutions' Off-label Use

Efficacy Clinical Trial

Official title:
The Effectivity and Toxicity of Methylsulfonic Apatinib for Extensively Pre-treated Advanced Sarcoma: a Multicentric Retrospective Study in China

Clinical Trial Summary

Anti-angiogenesis Tyrosine kinase inhibitors (TKIs) have been proved to show promising effects on prolonging progression-free survival (PFS) for advanced sarcoma after failure of standard multimodal Therapy. Methylsulfonic apatinib is one of those TKIs which specifically inhibits VEGFR-2. This study summarizes the experience of three Peking University affiliated hospitals in off-label use of apatinib in the treatment of extensively pre-treated sarcoma.

Clinical Trial Description

The investigators retrospectively analysed files of patients with advanced sarcoma not amenable to curative treatment, who were receiving an apatinib-containing regimen between June 1, 2015 and December 1, 2016. Fifty-six patients were included: 22 osteosarcoma, 10 Ewing's sarcoma, 3 chondrosarcoma and 21 soft tissue sarcoma. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03491371
Study type Interventional
Source Peking University People's Hospital
Contact
Status Completed
Phase N/A
Start date June 1, 2015
Completion date February 1, 2017
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