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Clinical Trial Summary

Decades of Tourette Syndrome (TS) neuroimaging research has revealed abnormal cortical and subcortical motor system network, hypothesized to result from maladaptive plasticity. Repetitive transcranial magnetic stimulation ([r]TMS) is a promising technology that utilizes the concept of neuroplasticity to modulate brain circuits. TMS modulation has the distinct advantage in terms of its non-invasive nature. Furthermore, unique stimulation paradigms such as intermittent theta-burst repetitive TMS (iTBS) allows for short stimulation time (<3 min). Using a sham-controlled protocol, the investigators propose modulating pre-SMA output using iTBS, based on our prior data of abnormal pre-SMA-mediated motor system regulation. hypothesize pre-SMA modulation results in increased pre-SMA-mediated motor inhibition. Enhancing these inhibitory measures with pre-SMA-iTBS provides the basis for improving inhibitory function in TS patients, leading to our long-term goal of neuro-stimulation to achieve clinical tic reduction.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05628805
Study type Interventional
Source Children's Hospital Medical Center, Cincinnati
Contact Molly Griffith
Phone 513-636-9669
Email molly.griffith@cchmc.org
Status Recruiting
Phase Early Phase 1
Start date November 1, 2022
Completion date February 17, 2025

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