Impulse Control in Gilles de la Tourette Syndrome

Tourette Syndrome Clinical Trial

Official title:

Do Mirror Neurons Play a Role in Tourette Syndrome Physiopathology? A Pilot Study.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04197804
• Other study ID #: Nessie (PI: M Porta)
• Secondary ID: L3035
• Status: Completed
• Start date: May 2, 2018
• Est. completion date: April 30, 2019

Study information

• Verified date: May 2023
• Source: Istituto Ortopedico Galeazzi
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The study intends to evaluate the role of Mirror Neurons in the determination of gestures, words, and repetitive vocalizations in subjects affected by Tourette's syndrome and to verify if these subjects are faster to assemble sounds, in phonology and morphology, than the non-pathological population.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: April 30, 2019
• Est. primary completion date: April 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 6 Years to 10 Years

Eligibility

Inclusion Criteria:

TOURETTE GROUP

• Consecutive patients belonging to the Tourette Center

• Caucasian

• Italian mother-tongue

• Age between 6 and 10 years completed

• Male and female 4: 1 (16 males and 4 females)

• Diagnosis of Tourette's syndrome for at least 1 year

• Presence of a value of YGTSS> 50%

NOT GROUP TOURETTE

• Caucasian

• Italian mother-tongue

• Age between 6 and 10 years completed

• Male and female 4: 1 (16 males and 4 females)

Exclusion Criteria:

TOURETTE GROUP

• Diagnosis of DSA

• Presence of significant psychiatric disorders, with the exception of those belonging to the Tourette Syndrome itself (eg ADHD, OCD).

NOT GROUP TOURETTE

• Diagnosis of DSA

• Presence of significant psychiatric disorders

Related Conditions & MeSH terms

• Syndrome
• Tourette Syndrome

Intervention

Other:
• Routine tests perform
The subjects of the Tourette group and control group are subjected to routine tests performed at Tourette Center and Extrapyramidal Diseases. Both groups are initially subjected to an evaluation that aims to identify the IQ and therefore 4 tasks are presented. The 1st (with a duration of about 2 and a half minutes) and the 2nd (with a duration of about 2 minutes) related to the motor field, the 3rd (with duration of about 1 minute) and the 4th (with duration about 3 minutes) the language field. These evaluations are in practice at the Center for Tourette patients; the tasks will be administered to both groups.

Locations

Country	Name	City	State
Italy	IRCCS Istituto Ortopedico Galeazzi	Milan

Sponsors (1)

Lead Sponsor	Collaborator
Istituto Ortopedico Galeazzi

Country where clinical trial is conducted

Italy, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Tourette syndrome and the imitation of gestures	The aim is to investigate the correlation between Mirror Neurons and Tourette Syndrome defining the greater propensity of the Tourettian subjects to imitate gestures, through the administration of the first Task	Through study completion, an average of 1 year