Total Knee Arthroplasty Clinical Trial
Official title:
The Analgesic Efficacy of Nitroglycerin Patches for Postoperative Pain in Patients Undergoing Total Knee Arthroplasty
Patients who undergo general anestheesia for total knee arthroplasty pften have sever postoperative pain which hinders their rehabilitation. Nitroglycerin patches have been found to cause alleviation of pain especially when used in conjuction with morphine. Therefore we propose placement of a nitroglycerin patch after total kneee arthroplasty surgery and see how it affects pain scores or causes less nedd for morphine after surgery.
Patients undergoing total knee arthroplasty will be randomized into two groups: control and
placebo.
Eache patient will undergo total knee arthroplasty under general anesthesia. Both groups
will get the same anesthetic protocal. At the end of surgery, before awakening patients will
recieve either a nitroglycerin or placebo patch on their back. Both the participant and the
investigator will be blinded to the group assisignment. At the end of surgery both groups
will recieve morphine for postoperative pain. In the recovery room they will be given
patient controlled analgesia with morphine. An investigator blinded to study assisignment
will record pain scores, sedation scores, nauseau and vomiting. Patients will be given
patient controlled analgesia for 24 hours and they will be followed for pain levels,
morphine use, sedation and nauseau levels. The nitroderm or placebo patch will be removed
after 24 hours.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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