Tonsillitis Clinical Trial
Official title:
A Randomized Controlled Study of 5 and 10 Days Treatment With Phenoxymethylpenicillin for Pharyngotonsillitis Caused by Streptococcus Group A
The primary objective of the study is to compare the clinical efficacy of 5 days (800 mg x 4) versus 10 days (1000 mg x 3) treatment with phenoxymethylpenicillin (PcV) in adults, adolescents and children with streptococcal tonsillitis. Patients are recruited from 17 primary Health care centres in the south of Sweden. Adult men and women, youth and children ≥ 6 years of age who are visiting the primary Health care for sore throat with suspected tonsillitis and meeting the criteria in accordance with current treatment recommendations for pharyngotonsillitis, ie 3-4 Centor criteria (fever≥ 38.5, tender lymph nodes, coatings of the tonsils and absence of cough) and a positive rapid antigen detection test (RADT) for Group A streptococcus (GAS) will be included in the study. Patients will be randomized to be prescribed PcV of 5 and 10 days. Each patient or guardian fills daily in a short diary including aches, fever, PcV doses, pain relievers, adverse events etc. Five to seven days after last intake of PcV the general practioner make a clinical judgement if the patient has recovered from the pharyngotonsillitis. Questions to be asked are if remaining symptoms or new symptoms of sore throat is present, if adverse events have been noted or of any extra physician visits have been made. Throat swab for semi quantitative cultures of Streptococcus group A, C and G are made at randomization and five to seven days after last intake of PcV. A study nurse will contact the patients one month and three months after the last treatment day for follow-up. If the patient has reconsulted or been hospitalised for a sore throat or possible complication, those patient records will be examined.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04083417 -
Sore Throat in Primary Care - a Comparison of Phenoxymethylpenicillin and no Antibiotic Treatment
|
Phase 4 | |
| Completed |
NCT04551196 -
Management of Post-Tonsillectomy Pain in Pediatric Patients
|
Phase 3 | |
| Active, not recruiting |
NCT03654742 -
Intracapsular Tonsillectomy in Adults
|
N/A | |
| Completed |
NCT04016051 -
Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections
|
Phase 3 | |
| Enrolling by invitation |
NCT02205580 -
Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children
|
Phase 4 | |
| Completed |
NCT01721486 -
Acetaminophen's Efficacy For Post-operative Pain
|
Phase 4 | |
| Active, not recruiting |
NCT01691690 -
Analgesic Effect of IV Acetaminophen in Tonsillectomies
|
Phase 2 | |
| Completed |
NCT00393744 -
Efficacy Study of Pristinamycin Versus Amoxicillin to Treat Tonsillitis Induced by Streptococcus in Children
|
Phase 3 | |
| Completed |
NCT00095368 -
APC-111 Once a Day (QD) for 7 Days vs. Penicillin Taken Four Times a Day (QID) for 10 Days in Patients With Strep Throat
|
Phase 3 | |
| Active, not recruiting |
NCT00136877 -
Tonsillectomy in Recurrent Tonsillitis
|
N/A | |
| Recruiting |
NCT04646525 -
The Relationship Between Covid-19 Infection in Pediatric Patients and Secondary Lymphoid Organs
|
||
| Completed |
NCT01361399 -
Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold
|
Phase 3 | |
| Recruiting |
NCT03137823 -
Diagnosis of GABHS Tonsillitis - Comparison Between Culture From Tonsills and Culture From the Bucal Surface
|
N/A | |
| Completed |
NCT02571075 -
Battlefield Auricular Acupuncture During Adult Tonsillectomies and Effect of Post op Pain and Nausea
|
N/A | |
| Completed |
NCT00547391 -
Recurrent Throat Infections and Tonsillectomy
|
Phase 4 | |
| Completed |
NCT00242281 -
APC-111 MP Tablet Once a Day vs.Penicillin VK Four Times a Day Both for 10 Days in Patients With Strep Throat
|
Phase 3 | |
| Completed |
NCT01465009 -
Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold
|
Phase 4 | |
| Recruiting |
NCT04164511 -
Does Ice Cream Help With Post-tonsillectomy Pain
|
||
| Completed |
NCT04653376 -
Relationship of Endoplasmic Reticulum Stress and Tonsillar Tissue Diseases
|
||
| Recruiting |
NCT06326983 -
Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
|
N/A |