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NCT00740896 Clinical Trial

Acute Effects of Smoking on Airway Dendritic Cells

Tobacco Use Disorder Clinical Trial

Official title:
Acute Effects of Smoking on Airway Dendritic Cells

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00740896
Other study ID # LO-2222
Secondary ID
Status Completed
Phase N/A
First received August 22, 2008
Last updated April 7, 2009
Start date June 2008
Est. completion date December 2008

Study information
Verified date April 2009
Source University of Rostock
Contact n/a
Is FDA regulated No
Health authority Germany: Ethics Commission
Study type Interventional

Clinical Trial Summary

Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Recruitment information / eligibility
Status Completed
Enrollment 16
Est. completion date December 2008
Est. primary completion date November 2008
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Active smoking (at least 10 cigarettes per day)

- Age > 18 years

Exclusion Criteria:

- Any chronic diseases

- Any regular medication

- Any signs or symptoms of an acute infection

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Intervention

Behavioral:
• Smoking
Active Comparator: Participants smoke 8 cigarettes in 4 hours.
• Smoking
Sham Comparator: Participants are not allowed to smoke for 4 hours.

Locations
Country Name City State
Germany University of Rostock Rostock

Sponsors (2)
Lead Sponsor Collaborator
University of Rostock German Research Foundation

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Bratke K, Klug M, Bier A, Julius P, Kuepper M, Virchow JC, Lommatzsch M. Function-associated surface molecules on airway dendritic cells in cigarette smokers. Am J Respir Cell Mol Biol. 2008 Jun;38(6):655-60. doi: 10.1165/rcmb.2007-0400OC. Epub 2008 Jan 18. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Total number of dendritic cells in bronchoalveolar lavage fluid June - September 2008 No
Secondary Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid June - September 2008 No
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