Tobacco Use Disorder Clinical Trial
Official title:
Effect of Smoking Exposure on Tobacco Self-Administration Following Brief Abstinence
Recent research on the effects of nicotine on the brain and behavior presents an opportunity
to advance medication development.
The purpose of this study is to develop a laboratory model for early-stage testing of new and
existing treatments for nicotine addiction. Specifically, the investigators will develop a
laboratory model of relapse to cigarette use in nicotine dependent volunteers.
Tobacco use is the leading preventable cause of death in the United States. Recent research
on the effects of nicotine on the brain and behavior presents an opportunity to advance
medication development. The goal of this study is to develop a laboratory model for
early-stage testing of new and existing compounds for the treatment of tobacco and nicotine
addiction. In addition, the objective of this study is to develop a laboratory model of
relapse induced by cigarette exposure that would reproduce the psychological and
physiological processes that are involved when abstinent individuals progress from initial
cigarette smoking (lapse) to a pre-abstinence level of use (relapse). Such a model may be
used to study the mechanisms of relapse and to screen medications that might be effective in
preventing relapse in treatment seekers.
This study will consist of two phases. Each phase will consist of a 5-day inpatient stay.
During the first portion of inpatient stay, participants will not be permitted to smoke.
During the second portion of inpatient stay, smoking reinstatement will be modeled, as
participant will have opportunity to smoke, following the exposure to tobacco-related or
control cues. A variety of behavioral, subjective, physiological, and performance measures
will be assessed throughout the study.
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