Optimal Flow Rate During Cardiopulmonary Bypass

Tissue Perfusion Clinical Trial

Official title: Optimal Flow Rate During Cardiopulmonary Bypass

Status Recruiting

Clinical Trial Summary

Regardless of the development of cardiac surgery techniques and technologies, the question of an optimal extracorporeal circulation is still unanswered. There are globally accepted standards of perfusion, however, keep many of these procedures was not evidence-based review.

Generally accepted are flow rates during cardiopulmonary bypasses of 2.5 L/min/m2. This target was derived from the physiological conditions, but they are not the result of an adapted adjustment to the fundamentally non-physiological processes during extracorporeal circulation. Among other things, an increased metabolic demand during re-perfusion is not taken into account.

An increasing and optimizing of the standard flow rate of 0.5 L/min/m2 should be the aim of this investigation. Under optimal perfusion, the investigators are maintaining the microcirculation and organ protection in receipt of endothelial function and oxygen transport.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Tissue Perfusion

• NCT number: NCT01105078
• Study type: Interventional
• Source: Johann Wolfgang Goethe University Hospitals
• Contact: Arndt H Kiessling, MD
• Phone: +49696301
• Email: arndt.kiessling@kgu.de
• Status: Recruiting
• Phase: N/A
• Start date: May 2010