Tissue Perfusion Clinical Trial
Official title:
Optimal Flow Rate During Cardiopulmonary Bypass
Regardless of the development of cardiac surgery techniques and technologies, the question
of an optimal extracorporeal circulation is still unanswered. There are globally accepted
standards of perfusion, however, keep many of these procedures was not evidence-based
review.
Generally accepted are flow rates during cardiopulmonary bypasses of 2.5 L/min/m2. This
target was derived from the physiological conditions, but they are not the result of an
adapted adjustment to the fundamentally non-physiological processes during extracorporeal
circulation. Among other things, an increased metabolic demand during re-perfusion is not
taken into account.
An increasing and optimizing of the standard flow rate of 0.5 L/min/m2 should be the aim of
this investigation. Under optimal perfusion, the investigators are maintaining the
microcirculation and organ protection in receipt of endothelial function and oxygen
transport.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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