Clinical Trials Logo

Clinical Trial Summary

This study evaluates predictability of fluid responsiveness of pressure-based dynamic variables such as pulse pressure variation and systolic pressure variation, according to tidal volume change in patients undergoing cardiac surgery.


Clinical Trial Description

Pressure-based dynamic variables such as pulse pressure variation(PPV) and systolic pressure variation(SPV) are known to be unreliable for prediction of fluid responsiveness in children. The hypothesis is that tidal volume change in mechanically ventilated children undergoing anesthesia would affect reliability of aforementioned dynamic variables in prediction of fluid responsiveness, especially in the way that reliability increases for high tidal volume. In children undergoing cardiac surgery, tidal volume is changed to 6mL/kg, 10mL/kg and 14mL/kg after closure of sternum, followed by measurement of PPV, SPV. We also measure the respiratory variation of aortic blood peak velocity(△Vpeak) via transesophageal echocardiography, which is known to best predict fluid responsiveness. Afterward, 10mL/kg of crystalloid solution is administered for fluid loading. 'Fluid responder' is defined as subjects with increase of stroke volume index more than 15% after fluid loading of 10mL/kg. With these data, whether the predictability of fluid responsiveness of PPV and SPV changes according to change in tidal volume is evaluated by comparing the area under the curve of the receiver-operating characteristics curve between themselves and △Vpeak. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03963089
Study type Interventional
Source Seoul National University Hospital
Contact
Status Completed
Phase N/A
Start date May 30, 2019
Completion date October 6, 2020

See also
  Status Clinical Trial Phase
Recruiting NCT04644458 - Use of Ulna Length to Predict Tidal Volume in Adult Egyptians
Recruiting NCT04036175 - Comparison of Patient Work of Breathing and Tidal Volumes With High Flow Nasal Cannula Oxygen Therapy and NIV (Non-Invasive Ventilation) After Extubation in the ICU. N/A
Recruiting NCT05812378 - Respiratory Monitoring System Safety and Performance Study
Recruiting NCT05056961 - Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study. N/A
Completed NCT02064140 - Supported Ventilation in ARDS Patients N/A
Recruiting NCT06215209 - Effect of PP in Patients With Ultra-low VT
Completed NCT03698799 - Adherence to LPV in SICU and Associated Clinical Outcomes