Serum Thyroglobulin as a Marker of Iodine Status During Pregnancy

Thyroid; Functional Disturbance Clinical Trial

Official title: Serum Thyroglobulin as a Marker of Iodine Nutrition Status During Pregnancy in Hungarian Population

Status Completed

Clinical Trial Summary

The purpose of the investigation is to assess iodine status of pregnant women at week 16 of gestation targeting serum thyroglobulin as a biomarker of iodine deficiency. The investigators aim to assess whether pre-gestational initiation of iodine supplementation is more advantageous in comparison to supplementation start at the time of pregnancy detection.

Clinical Trial Description

Mild iodine deficiency is still a public health issue in many industrialized countries, especially during pregnancy. During the last decade there was no monitoring of the iodine status in pregnancy in Hungary.

Since urinary iodine concentration (UIC) only reflects recent iodine intake and carries limited information on individual existing iodine stores, another biomarker e.g. measurement of serum thyroglobulin concentration, would be useful to gain comprehensive information. In the present study, the purpose of the investigation is to compare UIC, UIC normalized to creatinine concentration and serum thyroglobulin as biomarkers of iodine supply in pregnant women in a geographical region where previously iodine deficiency had been found.

UIC, serum thyroglobulin level and thyroid function are measured, and information about iodine supplementation and smoking before and during pregnancy are recorded. ;

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

• Dietary Iodine Deficiency
• Pathologic Processes
• Thyroid; Functional Disturbance

• NCT number: NCT02927119
• Study type: Observational
• Source: University of Debrecen
• Status: Completed
• Phase: N/A
• Start date: August 2014
• Completion date: December 2014