Thyroid Dysfunction Clinical Trial
Official title:
Thyroid Dysfunction in Patients With Nephrotic Syndrome
This study is to evaluate Thyroid Hormone profile in patients with Nephrotic syndrome to identify clinical predictor of Thyroid dysfunction in patients with Nephrotic syndrome
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | October 1, 2022 |
Est. primary completion date | October 1, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Nephrotic syndrome defined by the following: 1. Generalized edema 2. Urine protein excretion > 3,5 g/24 hours 3. Urine protein to creatinine ratio > 3,500mg/g 4. Serum albumin level less than 30 g/L Exclusion Criteria: - 1) Patients < 18 years old 2) Patients who have Thyroid diseases, current or past history of thyroid hormone or antithyroid drug intake. 3) Patients who have diabetes mellitus or autoimmune diseases as systemic lupus erythematosus and RA 4) Medications known to affect thyroid function. 5) Patients with liver cirrhosis and chronic liver disease as augmentin |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Merna Makram | Assiut University |
Bradley SE, Stéphan F, Coelho JB, Réville P. The thyroid and the kidney. Kidney Int. 1974 Nov;6(5):346-65. — View Citation
McCloskey O, Maxwell AP. Diagnosis and management of nephrotic syndrome. Practitioner. 2017 Feb;261(1801):11-5. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Hypothyroidism in patients with nephrotic syndrome | Decrease T3 and/or T4 and/or increase TSH in patients with proteinurea more than 3.5 mg | 1year |
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