Thyroid Cancer Clinical Trial
Official title:
Association Between Cancer Cells and Normal Vs. Low Levels of Thyroid Hormones in the Serum
Much experimental data has suggested that thyroid hormones (T3 and T4) may modulate
neoplastic cells and that T3/T4 deprivation may remove this stimulus. It is now well
established that T3/T4 affects cell division/angiogenesis through binding to integrin avb3,
commonly over-expressed on many cancer cells. In the experimental settings, mimicking
hypothyroidism in the cells is a difficult task. Currently, the use of charcoal stripped
serum is used. Using this method, the serum is stripped not only from T3 and T4, as
intended, but also from central and important cytokines and growth factor. This leads to a
reduced rate of cancer cell proliferation and thus, does not reflect the natural environment
in which cancer cells residue under hypothyroid conditions.
The investigators aim to characterize and establish the effects of serum from hypothyroid
patients on the proliferation/viability of a variety of cancer cell models.
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